ArticlePloS one2015
A mathematical model to elucidate brain tumor abrogation by immunotherapy with T11 target structure.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 93 citations in OpenAlex.
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- A mathematical model for COVID-19 transmission dynamics with a case study of India.Chaos, solitons, and fractals · 2020Article
- Modeling and forecasting the COVID-19 pandemic in India.Chaos, solitons, and fractals · 2020Article
- Forecasting the daily and cumulative number of cases for the COVID-19 pandemic in India.Chaos (Woodbury, N.Y.) · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure. We propose a mathematical model for brain tumor (glioma) and the immune system interactions, which aims in designing efficacious brain tumor therapy. The model encompasses considerations of the interactive dynamics of glioma cells, macrophages, cytotoxic T-lymphocytes (CD8(+) T-cells), TGF-β, IFN-γ and the T11TS. The system undergoes sensitivity analysis, that determines which state variables are sensitive to the given parameters and the parameters are estimated from the published data. Computer simulations were used for model verification and validation, which highlight the importance of T11 target structure in brain tumor therapy.
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