Evidence map›Paper›PMID 25955317›Full record

ArticleInternational journal of radiation biology2015

Role of the bradykinin B2 receptor in a rat model of local heart irradiation.

Benjamin J Lieblong, Vijayalakshmi Sridharan, Anup K Srivastava, Eduardo G Moros, Sunil K Sharma, Marjan Boerma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of radiation biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Benjamin J Lieblonga Department of Pharmacology and Toxicology , University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA.
Vijayalakshmi Sridharanb Division of Radiation Health, Department of Pharmaceutical Sciences , University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA.
Anup K Srivastavaa Department of Pharmacology and Toxicology , University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA.
Eduardo G Morosc Moffitt Cancer Center and Research Institute , Department of Radiation Oncology , Tampa, Florida , USA.
Sunil K Sharmab Division of Radiation Health, Department of Pharmaceutical Sciences , University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA.
Marjan Boermab Division of Radiation Health, Department of Pharmaceutical Sciences , University of Arkansas for Medical Sciences , Little Rock, Arkansas , USA.
University of Arkansas for Medical Sciences · USMoffitt Cancer Center · US

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2015 to 2024
$21.1M
Radiation-Induced Heart Disease: Mechanisms and InterventionsR01CA148679 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI BOERMA, MARJAN · 2010 to 2014
$1.4M
NCI NIH HHS CA148679NCI NIH HHS R01 CA148679NIGMS NIH HHS P20 GM109005
6 · The paper itself

Abstract

purposeRadiation-induced heart disease (RIHD) is a delayed effect of radiotherapy for cancers of the chest, such as breast, esophageal, and lung. Kinins are small peptides with cardioprotective properties. We previously used a rat model that lacks the precursor kininogen to demonstrate that kinins are involved in RIHD. Here, we examined the role of the kinin B2 receptor (B2R) in early radiation-induced signaling in the heart. MATERIALS AND

methodsMale Brown Norway rats received the B2R-selective antagonist HOE-140 (icatibant) via osmotic minipump from 5 days before until 4 weeks after 21 Gy local heart irradiation. At 4 weeks, signaling events were measured in left ventricular homogenates and nuclear extracts using western blotting and real-time polymerase chain reaction. Numbers of CD68-positive (monocytes/macrophages), CD2-positive (T-lymphocytes), and mast cells were measured using immunohistochemistry.

resultsRadiation-induced c-Jun phosphorylation and nuclear translocation were enhanced by HOE-140. HOE-140 did not modify endothelial nitric oxide synthase (eNOS) phosphorylation or alter numbers of CD2-positive or mast cells, but enhanced CD68-positive cell counts in irradiated hearts.

conclusionsB2R signaling may regulate monocyte/macrophage infiltration and c-Jun signals in the irradiated heart. Although eNOS is a main target for kinins, the B2R may not regulate eNOS phosphorylation in response to radiation.

Indexed as

AnimalsHeartHeart DiseasesMaleMyocardiumRadiation DosageRadiation InjuriesRadiotherapyRatsReceptor, Bradykinin B2Receptor, Bradykinin B2B2 receptorBradykininc-Junheartmacrophages

Identifiers

PMID25955317
PMCPMC4743985
OpenAlexW1761091606

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.