Evidence map›Paper›PMID 25955316›Full record

ArticlePloS one2015

The CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing.

Annick Mühlethaler-Mottet, Julie Liberman, Kelly Ascenção, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Nicolas Jauquier, Nicole Gross, Jean-Marc Joseph

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Review
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  4. Article
  5. Article
  6. Article
  7. Review
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  9. Review
  10. Evolution of Neuroendocrine Tumor Therapy.Surgical oncology clinics of North America · 2020
    Review
  11. PRIMA-1Journal of experimental & clinical cancer research : CR · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Annick Mühlethaler-MottetDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Julie LibermanDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Kelly AscençãoDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Marjorie FlahautDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Katia Balmas BourloudDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Pu YanDepartment of Pathology, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Nicolas JauquierDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Nicole GrossDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
Jean-Marc JosephDepartment of Pediatrics, University Hospital CHUV, University of Lausanne, Lausanne, Switzerland.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) is one of the most deadly solid tumors of the young child, for which new efficient and targeted therapies are strongly needed. The CXCR4/CXCR7/CXCL12 chemokine axis has been involved in the progression and organ-specific dissemination of various cancers. In NB, CXCR4 expression was shown to be associated to highly aggressive undifferentiated tumors, while CXCR7 expression was detected in more differentiated and mature neuroblastic tumors. As investigated in vivo, using an orthotopic model of tumor cell implantation of chemokine receptor-overexpressing NB cells (IGR-NB8), the CXCR4/CXCR7/CXCL12 axis was shown to regulate NB primary and secondary growth, although without any apparent influence on organ selective metastasis. In the present study, we addressed the selective role of CXCR4 and CXCR7 receptors in the homing phase of metastatic dissemination using an intravenous model of tumor cell implantation. Tail vein injection into NOD-scid-gamma mice of transduced IGR-NB8 cells overexpressing CXCR4, CXCR7, or both receptors revealed that all transduced cell variants preferentially invaded the adrenal gland and typical NB metastatic target organs, such as the liver and the bone marrow. However, CXCR4 expression favored NB cell dissemination to the liver and the lungs, while CXCR7 was able to strongly promote NB cell homing to the adrenal gland and the liver. Finally, coexpression of CXCR4 and CXCR7 receptors significantly and selectively increased NB dissemination toward the bone marrow. In conclusion, CXCR4 and CXCR7 receptors may be involved in a complex and organ-dependent control of NB growth and selective homing, making these receptors and their inhibitors potential new therapeutic targets.

Indexed as

Adrenal GlandsAnimalsBone MarrowCell ProliferationChemokine CXCL12Gene Expression Regulation, NeoplasticHumansLiverLungMiceNeoplasm InvasivenessNeoplasm MetastasisNeuroblastomaReceptors, CXCRReceptors, CXCR4Signal TransductionACKR3 protein, humanChemokine CXCL12CXCL12 protein, humanReceptors, CXCRReceptors, CXCR4

Identifiers

PMID25955316
PMCPMC4425663
OpenAlexW302273750

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.