ArticleBiophysical journal2015
Mechanochemical symmetry breaking in Hydra aggregates.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Mutual inhibition model of pattern formation: The role of Wnt-Dickkopf interactions in driving Hydra body axis formation.PLoS computational biology · 2026Article
- Modeling mechanochemical coupling in optogenetically activated cell layers.Biophysical journal · 2026Article
- Anisotropic stretch biases the self-organization of actin fibers in multicellular Hydra aggregates.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanochemical patterning localizes the organizer of a luminal epithelium.Science advances · 2025Article
- Mechanical characterization of regenerating Hydra tissue spheres.Biophysical journal · 2024Article
- Hydrostatic pressure as a driver of cell and tissue morphogenesis.Seminars in cell & developmental biology · 2022Review
- The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.BMC biology · 2021Article
- Pattern regulation in a regenerating jellyfish.eLife · 2020Article
- Mouth Function Determines the Shape Oscillation Pattern in Regenerating Hydra Tissue Spheres.Biophysical journal · 2019Article
- Sustained Oscillations of Epithelial Cell Sheets.Biophysical journal · 2019Article
- Post-Turing tissue pattern formation: Advent of mechanochemistry.PLoS computational biology · 2018Article
- Elongation and shape changes in organisms with cell walls: A dialogue between experiments and models.Cell surface (Amsterdam, Netherlands) · 2018Review
- Demystification of animal symmetry: symmetry is a response to mechanical forces.Biology direct · 2017Article
- Beyond Turing: mechanochemical pattern formation in biological tissues.Biology direct · 2016Article
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3 authors.
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Abstract
Tissue morphogenesis comprises the self-organized creation of various patterns and shapes. Although detailed underlying mechanisms are still elusive in many cases, an increasing amount of experimental data suggests that chemical morphogen and mechanical processes are strongly coupled. Here, we develop and test a minimal model of the axis-defining step (i.e., symmetry breaking) in aggregates of the Hydra polyp. Based on previous findings, we combine osmotically driven shape oscillations with tissue mechanics and morphogen dynamics. We show that the model incorporating a simple feedback loop between morphogen patterning and tissue stretch reproduces a wide range of experimental data. Finally, we compare different hypothetical morphogen patterning mechanisms (Turing, tissue-curvature, and self-organized criticality). Our results suggest the experimental investigation of bigger (i.e., multiple head) aggregates as a key step for a deeper understanding of mechanochemical symmetry breaking in Hydra.
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