Evidence map›Paper›PMID 25954719›Full record

ReviewJournal of clinical and diagnostic research : JCDR2015

Myoepithelial Cells (MEC) of the Salivary Glands in Health and Tumours.

Ravi Teja Chitturi, V Veeravarmal, R Madhavan Nirmal, B Venkat Ramana Reddy

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. [Expression of thymidylate synthase in salivary adenoid myoepithelial cells and its clinical significance].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020
    Article
  9. Article
  10. Article
  11. BRCA1/2 Mutations in Salivary Pleomorphic Adenoma and Carcinoma-ex-Pleomorphic Adenoma.Journal of International Society of Preventive & Community Dentistry · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Short histological kaleidoscope - recent findings in histology. Part III.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Article
  17. Article
  18. Primary cell culture and characterization of a pleomorphic adenoma. A case report.Revista cientifica odontologica (Universidad Cientifica del Sur)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ravi Teja ChitturiSenior Lecturer, Department of Oral Pathology, SIBAR Institute of Dental Sciences , Guntur, Andhra Pradesh, India .
V VeeravarmalProfessor, Department of Oral Pathology, Rajah Muthiah Dental College and Hospital , Annamalai Nagar, Tamil Nadu, India .
R Madhavan NirmalProfessor and HOD, Department of Oral Pathology, Rajah Muthiah Dental College and Hospital , Annamalai Nagar, Tamil Nadu, India .
B Venkat Ramana ReddyProfessor and HOD, Department of Oral Pathology, SIBAR Institute of Dental Sciences , Guntur, Andhra Pradesh, India .
Kamineni Institute of Dental Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myoepithelial cells (MEC) are found in the secretory units of many mammalian exocrine glands such as mammary, sweat, lacrimal and salivary glands. They are interposed between the secretory cells and the basal lamina. Immunohistochemically they are found to contain keratin intermediate filaments and are, therefore, considered to have an epithelial origin but at the same time they contain a large number of myofilaments which represent a massive expression of contractile proteins such as actin, myosin, calponin and caldesmon. Thus have smooth muscle like property also and hence the name. Numerous functions of MEC have been described, the most important of them being important for contraction of the glands and recently it has been found to prevent tumour progression. It should be noted that the diversity in the occurrence and dilemma regarding the pathogenesis of salivary gland tumours is due to lack in uniformity regarding the cells participating in its oncogenesis, especially the MEC. Also proper and extensive studies regarding MEC are very limited and thus have posed difficulty for a pathologist to understand this cell. In this review we try to bring about a thorough description of this cell in both physiological and pathological aspects.

Indexed as

FunctionsImmunohistochemical markersMyoepithelial cell expression in salivary gland tumours

Identifiers

PMID25954719
PMCPMC4413169
OpenAlexW2412817263

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.