Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD).

Dirk de Beer, Jan Völzmann, Christoph Kalka, Gabriela M Baerlocher

Abstract read

In one paragraph

Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.Computer methods in biomechanics and biomedical engineering. Imaging & visualization · 2018
Article

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Dirk de BeerExperimental Hematology, Department of Clinical Research, University of Bern, Bern Switzerland; Department of Hematology, University Hospital/Inselspital Bern , Bern, Switzerland .

Jan VölzmannDepartment of Clinical and Interventional Angiology, University Hospital Bern , Bern .

Christoph KalkaDepartment of Clinical and Interventional Angiology, University Hospital Bern , Bern .

Gabriela M BaerlocherExperimental Hematology, Department of Clinical Research, University of Bern, Bern Switzerland; Department of Hematology, University Hospital/Inselspital Bern , Bern, Switzerland .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Telomere attrition has been linked to accelerate vascular ageing and seems to predispose for vascular disease. Our aim was to study the telomere length dynamics over time and in subsets of leukocytes from 15 patients with peripheral arterial disease (PAD). The mean telomere length in subsets of leukocytes of patients with PAD was in the normal range of age-related telomere length values from healthy individuals. However, we found significant higher telomere attrition for T-cells from patients with PAD over a time period of six months when compared to the controls. The higher telomere loss in T-cells of patients with PAD most likely reflects a higher cell turnover of this leukocyte subset, which is involved in the process of chronic inflammatory disease underlying vascular disease. Further studies are needed to confirm these data and to assess how far this T-cell telomere attrition will correlate to the extent of the disease.

Indexed as

ArteriosclerosisCADPADTelomere length

Identifiers

PMID25954657

DOI10.7860/JCDR/2015/10931.5684

PMCPMC4413106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.