ArticleJournal of clinical and diagnostic research : JCDR2015
Study of Metastasis in Lymphnode Biopsies with Special Reference to Immunohistochemistry (IHC) in Metastatic Breast Carcinoma.
Article in Journal of clinical and diagnostic research : JCDR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 6 citations in OpenAlex.
- Metastatic Tumors from Unknown Primary in Cervical Lymph Nodes: A Decade of Study in a Tertiary Care Center of a Resource-Limited Country.JNMA; journal of the Nepal Medical Association · 2026Article
- Dual-energy computed tomography for evaluating nodal staging in lung adenocarcinoma: correlation with surgical pathology.Japanese journal of radiology · 2024Article
- Dual-Energy Computed Tomography in Detecting and Predicting Lymph Node Metastasis in Malignant Tumor Patients: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Efficacy of punarnavine in restraining organ-specific tumour progression in 4T1-induced murine breast tumour model.Inflammopharmacology · 2019Article
- Metastatic and non-metastatic lymph nodes: quantification and different distribution of iodine uptake assessed by dual-energy CT.European radiology · 2018Article
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
contextLymph nodes are the most common site of metastatic malignancy, and sometimes constitute the first clinical manifestation of the disease. Metastases are tumour implants discontinuous with the primary tumour. The characterization of a neoplasm as primary or metastatic has always troubled surgical pathologists.
aimTo study distribution of lymph node metastasis in North Karnataka region based on age, sex, location and morphological features, and to explore the utility of special stains and immunohistochemistry (IHC) in its diagnosis. MATERIALS AND
methodsThe present study includes 228 cases of lymph node metastasis studied over a 10-year period (July 2004- June 2014). The H&E slides were reviewed, special stains and IHC done wherever necessary.
resultsOut of 228 cases, maximum were seen between 2012-2014 (79 cases; 34.65%). Age ranged from 16-85y (Mean- 47.02) with female predominance (Male:Female 1:2.55.). In 186 cases (81.58%) more than one lymph node received, while in majority of cases (35.09%) size of the lymph node was between 1-2cms. Most common site of metastasis was axillary lymph nodes (33.77%) followed by cervical (22.50%) and pelvic (9.64%). Primary was mainly from breast carcinoma (33.77%) followed by squamous cell carcinoma (31.57%) and adenocarcinoma (10.52%). IHC in 60 cases with breast carcinoma metastasis showed ER positivity in 45.00%, PR positivity in 41.67% and HER2/neu positivity in 38.33%.
conclusionIdentification of the size, number, microscopic type and possible primary site of metastasis is important prognostically especially in breast carcinoma. This study elaborates the pattern of distribution of lymph node metastasis in North Karnataka region with IHC as an aid to diagnosis.
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