ArticleOncoimmunology
TAM macrophages promote growth and metastasis within the cancer ecosystem.
Article in Oncoimmunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Role of Host GPR120 in Mediating Dietary Omega-3 Fatty Acid Inhibition of Prostate Cancer.Journal of the National Cancer Institute · 2019Trial
- Efficacy of anti-LAG3 and anti-PD-1 combination checkpoint inhibitor therapy against head and neck squamous cell carcinoma in a genetically engineered mouse model.Oncoimmunology · 2025Article
- Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche.Nature communications · 2025Article
- Acinar cells modulate the tumor microenvironment through the promotion of M1 macrophage polarization via macrophage endocytosis in pancreatic cancer.Discover oncology · 2025Article
- Sphingosine kinase 1 promotes M2 macrophage infiltration and enhances glioma cell migration via the JAK2/STAT3 pathway.Scientific reports · 2025Article
- Tumors in the setting of dupilumab use: A review of the literature.The World Allergy Organization journal · 2025Review
- Organelle Specific Macrophage Engineered Vesicles Differentially Reprogram Macrophage Polarization.Advanced healthcare materials · 2024Article
- Dual STAT‑3 and IL‑6R inhibition with stattic and tocilizumab decreases migration, invasion and proliferation of prostate cancer cells by targeting the IL‑6/IL‑6R/STAT‑3 axis.Oncology reports · 2022Article
- Cancer stem cells and macrophages: molecular connections and future perspectives against cancer.Oncotarget · 2021Review
- High-dimensional Cytometry (ExCYT) and Mass Spectrometry of Myeloid Infiltrate in Clinically Localized Clear Cell Renal Cell Carcinoma Identifies Novel Potential Myeloid Targets for Immunotherapy.Molecular & cellular proteomics : MCP · 2020Article
- Article
- Prostate cancer research: The next generation; report from the 2019 Coffey-Holden Prostate Cancer Academy Meeting.The Prostate · 2020Review
- Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease.European urology oncology · 2019Article
- The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells.Clinical & experimental metastasis · 2019Article
- Tumor-associated macrophages: a short compendium.Cellular and molecular life sciences : CMLS · 2019Review
- Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma.Cellular and molecular life sciences : CMLS · 2018Article
- Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages.Oncotarget · 2018Review
- Tissue Phenomics for prognostic biomarker discovery in low- and intermediate-risk prostate cancer.Scientific reports · 2018Article
- Histone deacetylase 6 modulates macrophage infiltration during inflammation.Theranostics · 2018Article
- Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.Frontiers in immunology · 2018Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Cancer continues to be the major cause of morbidity and death of more than 500,000 people in the US annually. Alternatively activated macrophages (M2 macrophages or TAMs) can facilitate tumor invasiveness and metastasis. As an invasive species in the tumor microenvironment, they provide an ideal therapeutic target.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.