Evidence map›Paper›PMID 25954430›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2014

Clinical decision support for whole genome sequence information leveraging a service-oriented architecture: a prototype.

Brandon M Welch, Salvador Rodriguez-Loya, Karen Eilbeck, Kensaku Kawamoto

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Meeting the challenge: Health information technology's essential role in achieving precision medicine.Journal of the American Medical Informatics Association : JAMIA · 2021
    Article
  2. The genomic CDS sandbox: An assessment among domain experts.Journal of biomedical informatics · 2016
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brandon M WelchMedical University of South Carolina, Charleston, SC ; University of Utah, Salt Lake City, UT.
Salvador Rodriguez-LoyaUniversity of Sussex, East Sussex, United Kingdom.
Karen EilbeckUniversity of Utah, Salt Lake City, UT.
Kensaku KawamotoUniversity of Utah, Salt Lake City, UT.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Whole genome sequence (WGS) information could soon be routinely available to clinicians to support the personalized care of their patients. At such time, clinical decision support (CDS) integrated into the clinical workflow will likely be necessary to support genome-guided clinical care. Nevertheless, developing CDS capabilities for WGS information presents many unique challenges that need to be overcome for such approaches to be effective. In this manuscript, we describe the development of a prototype CDS system that is capable of providing genome-guided CDS at the point of care and within the clinical workflow. To demonstrate the functionality of this prototype, we implemented a clinical scenario of a hypothetical patient at high risk for Lynch Syndrome based on his genomic information. We demonstrate that this system can effectively use service-oriented architecture principles and standards-based components to deliver point of care CDS for WGS information in real-time.

Indexed as

Decision Support Systems, ClinicalElectronic Health RecordsGenomeKnowledge BasesBase SequenceColorectal Neoplasms, Hereditary NonpolyposisHealth Level SevenHumansSystems Integration

Identifiers

PMID25954430
PMCPMC4419907

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.