Evidence map›Paper›PMID 25954326›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2014

Development of an Alert System to Detect Drug Interactions with Herbal Supplements using Medical Record Data.

Melissa Archer, Joshua Proulx, Laura Shane-McWhorter, Bruce E Bray, Qing Zeng-Treitler

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Melissa ArcherVA Salt Lake City Health Care System, Salt Lake City, UT ; University Of Utah College Of Pharmacy, salt lake city, UT.
Joshua ProulxVA Salt Lake City Health Care System, Salt Lake City, UT ; University of Utah Department of Biomedical Informatics, Salt Lake City, UT.
Laura Shane-McWhorterUniversity Of Utah College Of Pharmacy, salt lake city, UT.
Bruce E BrayVA Salt Lake City Health Care System, Salt Lake City, UT ; University of Utah Department of Biomedical Informatics, Salt Lake City, UT.
Qing Zeng-TreitlerVA Salt Lake City Health Care System, Salt Lake City, UT ; University of Utah Department of Biomedical Informatics, Salt Lake City, UT.

Funding

Protect Patient Safety Through Herb-Drug-Disease Interaction Detection and AlertR01AT006548 · NCCIH · UNIVERSITY OF UTAH · PI ZENG, QING · 2012 to 2014
$1.1M
Assist Patients with Medication DecisionsR01LM011334 · NLM · UNIVERSITY OF UTAH · PI ZENG, QING · 2012 to 2014
$919k
NCCIH NIH HHS R01 AT006548NLM NIH HHS R01 LM011334
6 · The paper itself

Abstract

While potential medication-to-medication interaction alerting engines exist in many clinical applications, few systems exist to automatically alert on potential medication to herbal supplement interactions. We have developed a preliminary knowledge base and rules alerting engine that detects 259 potential interactions between 9 supplements, 62 cardiac medications, and 19 drug classes. The rules engine takes into consideration 12 patient risk factors and 30 interaction warning signs to help determine which of three different alert levels to categorize each potential interaction. A formative evaluation was conducted with two clinicians to set initial thresholds for each alert level. Additional work is planned add more supplement interactions, risk factors, and warning signs as well as to continue to set and adjust the inputs and thresholds for each potential interaction.

Indexed as

Electronic Health RecordsHerb-Drug InteractionsKnowledge BasesMedical Order Entry SystemsDietary SupplementsHumansMedication ErrorsRisk Factors

Identifiers

PMID25954326
PMCPMC4419942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.