ArticleEvidence-based complementary and alternative medicine : eCAM2015
Antiulcerogenic Activity and Toxicity of Bauhinia holophylla Hydroalcoholic Extract.
Article in Evidence-based complementary and alternative medicine : eCAM, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- "Cow's Hoof" (Plants (Basel, Switzerland) · 2022Review
- Maslinic Acid: A New Compound for the Treatment of Multiple Organ Diseases.Molecules (Basel, Switzerland) · 2022Review
- Flavonoid-Rich Fractions ofPlants (Basel, Switzerland) · 2022Article
- Safety assessment ofToxicology research · 2021Article
- Validated spectrophotometric method for quantification of total triterpenes in plant matrices.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2020Article
- Hypoglycaemic activity of Bauhinia holophylla through GSK3-β inhibition and glycogenesis activation.Pharmaceutical biology · 2019Article
- Antioxidant and Antiulcerogenic Activity of the Dry Extract of Pods ofOxidative medicine and cellular longevity · 2019Article
- Constituents of leaves from Bauhinia curvula Benth. exert gastroprotective activity in rodents: role of quercitrin and kaempferol.Inflammopharmacology · 2018Article
- Phytochemical study and evaluation of cytotoxicity, mutagenicity, cell cycle kinetics and gene expression of Bauhinia holophylla (Bong.) Steud. in HepG2 cells in vitro.Cytotechnology · 2018Article
- Gastroprotective activity of the methanol extract from peels of Plinia edulis (Vell.) Sobral fruits and its isolated triterpenes: maslinic and ursolic acids.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Vanillin abrogates ethanol induced gastric injury in rats via modulation of gastric secretion, oxidative stress and inflammation.Toxicology reports · 2016Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several species of Bauhinia are used in traditional medicine for the treatment of gastrointestinal diseases, diabetes, and inflammation, among other conditions. The aim of this study was to investigate the antiulcer effect of a hydroalcoholic extract from the leaves of B. holophylla. The chemical profile of the extract was determined by HPLC-PAD-ESI-IT-MS. A dose-effect relation was constructed using the ethanol-induced gastric ulcer model in male Wistar rats. Histological analyses and studies of antioxidant and anti-inflammatory activities were performed in stomach samples. The involvement of SH compounds, NO, K(+) ATP channels, and α 2-adrenergic receptors in the gastroprotective effect was evaluated. A toxicity study was performed with a single oral dose of 5000 mg/kg. The extract was composed mainly of cyanoglucoside and flavonol-O-glycosides derivatives of quercetin and myricetin. SH compounds, NO release, K(+) ATP channel activation, and presynaptic α 2-adrenergic receptor stimulation each proved to be involved in the antiulcer effect. The levels of GSH and activity of GR and GPx were increased, and the levels of TNF-α, IL-6 and IL-10 were modulated. There was an antidiarrheal effect and there were no signs of toxicity. B. holophylla presents antiulcer activity mainly by decreasing oxidative stress and attenuating the inflammatory response, without inducing side effects.
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Registered trials
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