Evidence map›Paper›PMID 25954245›Full record

ArticleFrontiers in neurology2015

A clinical and biochemical analysis in the differential diagnosis of idiopathic normal pressure hydrocephalus.

Tommaso Schirinzi, Giulia Maria Sancesario, Cristiano Ialongo, Paola Imbriani, Graziella Madeo, Sofia Toniolo, Alessandro Martorana, Antonio Pisani

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 3 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Cerebrospinal Fluid Biomarkers in iNPH: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022
    Review
  8. Observational
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. CSF biomarkers distinguish idiopathic normal pressure hydrocephalus from its mimics.Journal of neurology, neurosurgery, and psychiatry · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tommaso SchirinziDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy.
Giulia Maria SancesarioIRCCS Santa Lucia Foundation , Rome , Italy.
Cristiano IalongoDepartment of Experimental Medicine and Surgery, University of Rome "Tor Vergata" , Rome , Italy.
Paola ImbrianiDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy.
Graziella MadeoDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy.
Sofia TonioloDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy.
Alessandro MartoranaDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy.
Antonio PisaniDepartment of Systems Medicine, University of Rome "Tor Vergata" , Rome , Italy ; IRCCS Santa Lucia Foundation , Rome , Italy.
University of Rome Tor Vergata · ITFondazione Santa Lucia · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIdiopathic normal pressure hydrocephalus (iNPH) can be misdiagnosed with other neurodegenerative diseases, especially in the early disease stages. Considering the opportunity of the shunt surgery, iNPH should be diagnosed with accuracy. Here, we evaluate the utility of CSF biomarkers and their relationship with clinical features in the diagnosis of iNPH.

methodsWe performed a multivariate analysis of the CSF levels of Aβ42, t-tau, and p-tau collected from four groups of patients: 14 iNPH, 14 progressive supranuclear palsy (PSP), 14 Alzheimer's disease (AD), 14 controls (CTL). Diagnostic accuracy of biomarkers was determined by the receiver operating characteristic curve analysis. Statistical correlation was calculated between each CSF biomarker and single clinical items of iNPH.

resultsAβ42 levels in iNPH were lower than controls, although not as low as in AD. Likewise, CSF t-tau and p-tau were lower in iNPH than in controls. Of interest, t-tau and p-tau were higher in AD than in controls and hence both t-tau and p-tau were significantly lower in iNPH than in AD. No differences were found between iNPH and PSP. CSF biomarkers levels did not correlate to clinical features of iNPH, whereas two significant correlations emerged within clinical parameters: cognitive impairment was related to gait difficulties, while ventricular enlargement correlated with continence disturbances.

conclusionMeasurement of CSF biomarker levels may be helpful in the differential diagnosis between iNPH and AD but not between iNPH and PSP. Both Aβ42 and tau levels appear unrelated to main clinical features of iNPH.

Indexed as

CSF biomarkersidiopathic normal pressure hydrocephalusprogressive supranuclear palsy

Identifiers

PMID25954245
PMCPMC4407581
OpenAlexW2004445483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.