Evidence map›Paper›PMID 25954175›Full record

ArticleFrontiers in human neuroscience2015

Age-related slowing of response selection and production in a visual choice reaction time task.

David L Woods, John M Wyma, E William Yund, Timothy J Herron, Bruce Reed

Erratum issued 2 registry-linked trialsAbstract read
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01022307 completednot on this map

Quantitative Automated Lesion Detection of TBI

TypeobservationalSponsorVA Office of Research and DevelopmentRan2009 to 2014Enrolled212ConditionsTraumatic Brain Injury
NCT04800588 narecruitingnot on this mapstarted 2021, after this paper: background citation

Computerized Tests of Cognitive Decline in Presymptomatic Alzheimer's Disease

TypeinterventionalSponsorNeurobehavioral Systems, Inc.Ran2021 to 2027Enrolled2,000ConditionsAlzheimer Disease, Cognitive Decline, AgingArmsCalifornia Cognitive Assessment Battery
3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Trial
  2. Article
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  5. A Robotic Assistance With Specialized Timing Improves Motor Performance: Implications for Movement Training.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
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  14. Impaired face symmetry detection under alcohol, but no 'beer goggles' effect.Journal of psychopharmacology (Oxford, England) · 2024
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

David L WoodsHuman Cognitive Neurophysiology Laboratory, Veterans Affairs Northern California Health Care System Martinez, CA, USA ; The Department of Neurology, University of California Davis Sacramento, CA, USA ; Center for Neurosciences, University of California Davis CA, USA ; Center for Mind and Brain, University of California Davis CA, USA.
John M WymaHuman Cognitive Neurophysiology Laboratory, Veterans Affairs Northern California Health Care System Martinez, CA, USA.
E William YundHuman Cognitive Neurophysiology Laboratory, Veterans Affairs Northern California Health Care System Martinez, CA, USA.
Timothy J HerronHuman Cognitive Neurophysiology Laboratory, Veterans Affairs Northern California Health Care System Martinez, CA, USA.
Bruce ReedThe Department of Neurology, University of California Davis Sacramento, CA, USA ; Alzheimer's Disease Center, Department of Neurology, University of California Davis CA, USA.

Funding

Effects of Long-Term Low Level Hydrogen Sulfide ExposureR01ES014038 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATES, MICHAEL N · 2006 to 2010
$2.6M
Quantitative automated lesion detection (QALD) in moderate and severe TBII01CX001000 · VA · VA NORTHERN CALIFORNIA HEALTH CARE SYS · PI DRONKERS, NINA F. · 2014 to 2017
–
CSRD VA I01 CX001000NIEHS NIH HHS R01 ES014038
6 · The paper itself

Abstract

Aging is associated with delayed processing in choice reaction time (CRT) tasks, but the processing stages most impacted by aging have not been clearly identified. Here, we analyzed CRT latencies in a computerized serial visual feature-conjunction task. Participants responded to a target letter (probability 40%) by pressing one mouse button, and responded to distractor letters differing either in color, shape, or both features from the target (probabilities 20% each) by pressing the other mouse button. Stimuli were presented randomly to the left and right visual fields and stimulus onset asynchronies (SOAs) were adaptively reduced following correct responses using a staircase procedure. In Experiment 1, we tested 1466 participants who ranged in age from 18 to 65 years. CRT latencies increased significantly with age (r = 0.47, 2.80 ms/year). Central processing time (CPT), isolated by subtracting simple reaction times (SRT) (obtained in a companion experiment performed on the same day) from CRT latencies, accounted for more than 80% of age-related CRT slowing, with most of the remaining increase in latency due to slowed motor responses. Participants were faster and more accurate when the stimulus location was spatially compatible with the mouse button used for responding, and this effect increased slightly with age. Participants took longer to respond to distractors with target color or shape than to distractors with no target features. However, the additional time needed to discriminate the more target-like distractors did not increase with age. In Experiment 2, we replicated the findings of Experiment 1 in a second population of 178 participants (ages 18-82 years). CRT latencies did not differ significantly in the two experiments, and similar effects of age, distractor similarity, and stimulus-response spatial compatibility were found. The results suggest that the age-related slowing in visual CRT latencies is largely due to delays in response selection and production.

Indexed as

agingexecutive functionhandednesshemispheremotorprocessing speedreplicationtiming

Identifiers

PMID25954175
PMCPMC4407573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.