ArticleFrontiers in cellular neuroscience2015
Inducible and combinatorial gene manipulation in mouse brain.
Article in Frontiers in cellular neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
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- Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams.iScience · 2023Article
- Prefrontal engrams of long-term fear memory perpetuate pain perception.Nature neuroscience · 2023Article
- Perinatal exposure to tetracycline contributes to lasting developmental effects on offspring.Animal microbiome · 2021Article
- The Claustrum is Involved in Cognitive Processes Related to the Classical Conditioning of Eyelid Responses in Behaving Rabbits.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.Frontiers in synaptic neuroscience · 2019Article
- The cre-inducer doxycycline lowers cytokine and chemokine transcript levels in the gut of mice.Journal of applied genetics · 2017Article
- Flexible, AAV-equipped Genetic Modules for Inducible Control of Gene Expression in Mammalian Brain.Molecular therapy. Nucleic acids · 2016Article
- General Anesthetic Conditions Induce Network Synchrony and Disrupt Sensory Processing in the Cortex.Frontiers in cellular neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have deployed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate 'when', 'where', and 'how' gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.