Evidence map›Paper›PMID 25954099›Full record

ArticleWorld journal of gastroenterology2015

Low contrast medium and radiation dose for hepatic computed tomography perfusion of rabbit VX2 tumor.

Cai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang

Open access · hybridAbstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cai-Yuan ZhangCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Yan-Fen CuiCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Chen GuoCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Jing CaiCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Ya-Fang WengCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Li-Jun WangCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Deng-Bin WangCai-Yuan Zhang, Yan-Fen Cui, Chen Guo, Jing Cai, Ya-Fang Weng, Li-Jun Wang, Deng-Bin Wang, Department of Radiology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Heritage Christian University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the feasibility of low contrast medium and radiation dose for hepatic computed tomography (CT) perfusion of rabbit VX2 tumor.

methodsEleven rabbits with hepatic VX2 tumor underwent perfusion CT scanning with a 24-h interval between a conventional tube potential (120 kVp) protocol with 350 mgI/mL contrast medium and filtered back projection, and a low tube potential (80 kVp) protocol with 270 mgI/mL contrast medium with iterative reconstruction. Correlation and agreement among perfusion parameters acquired by the conventional and low dose protocols were assessed for the viable tumor component as well as whole tumor. Image noise and tumor-to-liver contrast to noise ratio during arterial and portal venous phases were evaluated.

resultsA 38% reduction in contrast medium dose (360.1 ± 13.3 mgI/kg vs 583.5 ± 21.5 mgI/kg, P < 0.001) and a 73% decrease in radiation dose (1898.5 mGy • cm vs 6951.8 mGy • cm) were observed. Interestingly, there was a strong positive correlation in hepatic arterial perfusion (r = 0.907, P < 0.001; r = 0.879, P < 0.001), hepatic portal perfusion (r = 0.819, P = 0.002; r = 0.831, P = 0.002), and hepatic blood flow (r = 0.945, P < 0.001; r = 0.930, P < 0.001) as well as a moderate correlation in hepatic perfusion index (r = 0.736, P = 0.01; r = 0.636, P = 0.035) between the low dose protocol with iterative reconstruction and the conventional protocol for the viable tumor component and the whole tumor. These two imaging protocols provided a moderate but acceptable agreement for perfusion parameters and similar tumor-to-liver CNR during arterial and portal venous phases (5.63 ± 2.38 vs 6.16 ± 2.60, P = 0.814; 4.60 ± 1.27 vs 5.11 ± 1.74, P = 0.587).

conclusionCompared with the conventional protocol, low contrast medium and radiation dose with iterative reconstruction has no significant influence on hepatic perfusion parameters for rabbits VX2 tumor.

Indexed as

Multidetector Computed TomographyRadiation DosageAnimalsBlood Flow VelocityContrast MediaFeasibility StudiesIohexolLiver Neoplasms, ExperimentalMicrovesselsPerfusion ImagingPredictive Value of TestsRabbitsRadiographic Image Interpretation, Computer-AssistedRegional Blood FlowContrast MediaIohexolLiverLow concentration contrast mediumLow radiation dosePerfusion computed tomographyVX2 tumor

Identifiers

PMID25954099
PMCPMC4419066
OpenAlexW614650016

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.