Evidence map›Paper›PMID 25954038›Full record

ReviewHuman reproduction (Oxford, England)2015

Enough! Stop the arguments and get on with the science of natural killer cell testing.

Gavin Sacks

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human reproduction (Oxford, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  5. Review
  6. Review
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  9. Article
  10. Prednisolone and enoxaparin (clexane) therapy ('the Bondi protocol') for repeated IVF failure.American journal of reproductive immunology (New York, N.Y. : 1989) · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Gavin SacksIvfaustralia, Westfield Tower 2, 101 Grafton Street, Bondi Junction, Sydney, Australia University of New South Wales, Sydney, Australia St George Hospital and Royal Hospital for Women, Sydney, Australia gsacks@ivf.com.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural killer cell testing is currently practised widely, and there are studies indicating potential benefit in terms of targeting women with repeated reproductive failure for immune therapy. This may be a better approach than empirical immune therapy without any investigation. More and better studies are needed before such an approach can be fully endorsed. There is still uncertainty over the precise pathophysiological basis for all immune investigation and therapy, but this should not be a barrier for clinical observation and empirical care. On the contrary, clinicians and researchers should work more closely together to provide the best care for our patients.

Indexed as

AdultFemaleHumansImmunotherapyInfertility, FemaleKiller Cells, NaturalUterusIVF failureperipheral blood natural killer cellsrecurrent miscarriagereproductive immune therapyuterine natural killer cells

Identifiers

PMID25954038

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.