Evidence map›Paper›PMID 25953958›Full record

ArticleG3 (Bethesda, Md.)2015

XSim: Simulation of Descendants from Ancestors with Sequence Data.

Hao Cheng, Dorian Garrick, Rohan Fernando

Abstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Bridging tradition and innovation: a review of computer simulations in plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hao ChengDepartment of Animal Science, Iowa State University, Ames, Iowa 50011-3150 Department of Statistics, Iowa State University, Ames, Iowa 50011-3150.
Dorian GarrickDepartment of Animal Science, Iowa State University, Ames, Iowa 50011-3150 Institute of Veterinary, Animal, and Biomedical Science, Massey University, Palmerston North, 4442, New Zealand.
Rohan FernandoDepartment of Animal Science, Iowa State University, Ames, Iowa 50011-3150 rohan@iastate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Real or imputed high-density SNP genotypes are routinely used for genomic prediction and genome-wide association studies. Many researchers are moving toward the use of actual or imputed next-generation sequence data in whole-genome analyses. Simulation studies are useful to mimic complex scenarios and test different analytical methods. We have developed the software tool XSim to efficiently simulate sequence data in descendants in arbitrary pedigrees. In this software, a strategy to drop-down origins and positions of chromosomal segments rather than every allele state is implemented to simulate sequence data and to accommodate complicated pedigree structures across multiple generations. Both C++ and Julia versions of XSim have been developed.

Indexed as

Genome-Wide Association StudySoftwareGenotypePolymorphism, Single Nucleotidegenome-wide association studiesgenomic predictiongenomic selectionGenPredpedigreesequence datashared data resourcesimulation

Identifiers

PMID25953958
PMCPMC4502375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.