Evidence map›Paper›PMID 25953926›Full record

ReviewCirculation research2015

Molecular controls of arterial morphogenesis.

Michael Simons, Anne Eichmann

Abstract readReview
In one paragraph

Review in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Bioengineering vascularization.Development (Cambridge, England) · 2024
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Receptor Tyrosine Kinase: Still an Interesting Target to Inhibit the Proliferation of Vascular Smooth Muscle Cells.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2023
    Review
  12. Endothelial cell direct reprogramming: Past, present, and future.Journal of molecular and cellular cardiology · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Environmental and intrinsic modulations of venous differentiation.Cellular and molecular life sciences : CMLS · 2022
    Article
  17. FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael SimonsFrom the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (M.S., A.E.) and Departments of Cell Biology (M.S.) and Molecular Physiology (A.E.), Yale University School of Medicine, New Haven, CT. michael.simons@yale.edu anne.eichmann@yale.edu.
Anne EichmannFrom the Department of Internal Medicine, Yale Cardiovascular Research Center, Section of Cardiovascular Medicine (M.S., A.E.) and Departments of Cell Biology (M.S.) and Molecular Physiology (A.E.), Yale University School of Medicine, New Haven, CT. michael.simons@yale.edu anne.eichmann@yale.edu.

Funding

Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2012 to 2022
$18.8M
SYNDECAN FUNCTION IN ENDOTHELIAL CELLSR01HL062289 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 1999 to 2021
$9.6M
Angiogensis and ischemiaR01HL053793 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 1996 to 2017
$7.3M
Arteriogenesis and BranchingR01HL084619 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL · 2007 to 2018
$6.7M
Targeting endothelial migration to prevent neovascularizationR01HL125811 · NHLBI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2015 to 2025
$4.1M
Role of Neuropilin receptors in lymphangiogenesisR01HL111504 · NHLBI · YALE UNIVERSITY · PI EICHMANN, ANNE CHRISTINE · 2012 to 2015
$1.6M
NHLBI NIH HHS HL053793NHLBI NIH HHS HL062289NHLBI NIH HHS P01 HL107205NHLBI NIH HHS R01 HL053793NHLBI NIH HHS R01 HL062289NHLBI NIH HHS R01 HL084619NHLBI NIH HHS R01 HL 111504NHLBI NIH HHS R01 HL111504NHLBI NIH HHS R01 HL125811
6 · The paper itself

Abstract

Formation of arterial vasculature, here termed arteriogenesis, is a central process in embryonic vascular development as well as in adult tissues. Although the process of capillary formation, angiogenesis, is relatively well understood, much remains to be learned about arteriogenesis. Recent discoveries point to the key role played by vascular endothelial growth factor receptor 2 in control of this process and to newly identified control circuits that dramatically influence its activity. The latter can present particularly attractive targets for a new class of therapeutic agents capable of activation of this signaling cascade in a ligand-independent manner, thereby promoting arteriogenesis in diseased tissues.

Indexed as

Neovascularization, PhysiologicAngiogenesis Inducing AgentsAnimalsArteriesEndothelial CellsGene Expression Regulation, DevelopmentalHumansMolecular Targeted TherapyMuscle, Smooth, VascularMyocytes, Smooth MuscleSignal TransductionVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2Angiogenesis Inducing AgentsKDR protein, humanVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2VEGFA protein, humanangiogenesis factorarteriesarteriogenesisvascular endothelial growth factor A

Identifiers

PMID25953926
PMCPMC4509635

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.