Evidence map›Paper›PMID 25953924›Full record

ArticleCirculation research2015

Cold-Inducible RNA-Binding Protein Regulates Cardiac Repolarization by Targeting Transient Outward Potassium Channels.

Jun Li, Duanyang Xie, Jian Huang, Fei Lv, Dan Shi, Yi Liu, Li Lin, Li Geng, Yufei Wu, Dandan Liang and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in Circulation research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 50 citations in OpenAlex.

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  7. Chronic Kidney Disease Induces Proarrhythmic Remodeling.Circulation. Arrhythmia and electrophysiology · 2023
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  8. Recent Advances in the Production of Genome-Edited Rats.International journal of molecular sciences · 2022
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Therapeutic genome editing in cardiovascular diseases.Advanced drug delivery reviews · 2021
    Review
  14. Article
  15. Extracellular CIRP (eCIRP) and inflammation.Journal of leukocyte biology · 2019
    Review
  16. Article
  17. A novelOncotarget · 2017
    Article
  18. Review
  19. From engineering to editing the rat genome.Mammalian genome : official journal of the International Mammalian Genome Society · 2017
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jun LiFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Duanyang XieFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Jian HuangFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Fei LvFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Dan ShiFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Yi LiuFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Li LinFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Li GengFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Yufei WuFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Dandan LiangFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.).
Yi-Han ChenFrom the Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine (J.L., D.X., J.H., F.L., D.S., Y.L., L.L., L.G., Y.W., D.L., Y.-H.C.); Institute of Medical Genetics, Tongji University (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine (J.L., D.S., Y.L., L.L., D.L., Y.-H.C.); Department of Cardiology, East Hospital, Tongji University School of Medicine (D.X., J.H., F.L., L.G., Y.W., Y.-H.C.) and Department of Pathology and Pathophysiology, Tongji University School of Medicine, Shanghai, China (Y.-H.C.). yihanchen@tongji.edu.cn.
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleCold-inducible RNA-binding protein (CIRP) is constitutively expressed at low levels across various tissues. It is rapidly upregulated by multiple stresses, underlying a general role for CIRP in organic adaptations to pathophysiological conditions. However, the role of CIRP in the heart remains unclear.

objectiveTo examine the biofunctions of CIRP in the mammalian heart. METHODS AND

resultsRats with targeted disruption of Cirp were generated using the TALEN (transcription activator-like effector nucleases)-based genome editing technique. The Cirp-knockout rats had structurally and functionally normal hearts. Resting ECG recordings revealed a short rate-corrected QT (QTc) interval in Cirp-null rats without any abnormalities in PR interval, RR interval or QRS waves as compared to wild-type animals. The shortened QTc interval from Cirp ablation was tightly linked to an abbreviated action potential duration in cardiac myocytes, which was attributable to increased transient outward potassium current (Ito). Furthermore, our findings uncovered that CIRP protein selectively bonded to KCND2 and KCND3 mRNAs encoding the functional α-subunits of Ito channel proteins. CIRP deficiency did not change the transcriptional activity of KCND2 or KCND3, but it facilitated their translation. Cirp knockout had no effect on the functional expression of ion channels other than Ito channels.

conclusionsCIRP modulates cardiac repolarization by negatively adjusting the expression and function of Ito channels. Our study may open a window to decipher the potential function of RNA-binding proteins in bioelectric activity.

Indexed as

Action PotentialsAnimalsBinding SitesCells, CulturedCold Shock Proteins and PeptidesGenotypeHeart RateIon Channel GatingKv Channel-Interacting ProteinsMyocytes, CardiacPhenotypeProtein BindingRats, TransgenicRNA-Binding ProteinsRNA, MessengerShal Potassium ChannelsCirbp protein, ratCold Shock Proteins and PeptidesKcnd2 protein, ratKcnd3 protein, ratKcnip2 protein, ratKv Channel-Interacting ProteinsRNA-Binding ProteinsRNA, MessengerShal Potassium Channelsaction potentialcardiaccold shock proteinsion channelsmyocytesrepolarization

Identifiers

PMID25953924
OpenAlexW1967708723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.