Evidence map›Paper›PMID 25953780›Full record

ArticleBrain : a journal of neurology2015

Is CHCHD10 Pro34Ser pathogenic for frontotemporal dementia and amyotrophic lateral sclerosis?

Carol Dobson-Stone, Alex D Shaw, Marianne Hallupp, Lauren Bartley, Heather McCann, William S Brooks, Clement T Loy, Peter R Schofield, Karen A Mather, Nicole A Kochan and 5 more

Abstract readLetterComment
PubMed Publisher
In one paragraph

Article in Brain : a journal of neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Pooled it
  2. Combined impact ofFrontiers in neurology · 2025
    Article
  3. Article
  4. Article
  5. ALS: Recent Developments from Genetics Studies.Current neurology and neuroscience reports · 2016
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Carol Dobson-Stone1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia j.kwok@neura.edu.au.
Alex D Shaw1 Neuroscience Research Australia, Sydney, NSW, Australia 3 Schizophrenia Research Institute, Sydney, NSW, Australia.
Marianne Hallupp1 Neuroscience Research Australia, Sydney, NSW, Australia.
Lauren Bartley1 Neuroscience Research Australia, Sydney, NSW, Australia.
Heather McCann1 Neuroscience Research Australia, Sydney, NSW, Australia.
William S Brooks1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Clement T Loy4 Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.
Peter R Schofield1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Karen A Mather5 School of Public Health, University of Sydney, Sydney, NSW, Australia.
Nicole A Kochan5 School of Public Health, University of Sydney, Sydney, NSW, Australia.
Perminder S Sachdev5 School of Public Health, University of Sydney, Sydney, NSW, Australia 6 Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
Glenda M Halliday1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
Olivier Piguet1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
John R Hodges1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
John B J Kwok1 Neuroscience Research Australia, Sydney, NSW, Australia 2 School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisDNA, MitochondrialFemaleFrontotemporal DementiaHumansMaleMitochondriaMitochondrial DiseasesMitochondrial ProteinsDNA, MitochondrialMitochondrial Proteins

Identifiers

PMID25953780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.