ArticleAJNR. American journal of neuroradiology2015
Diffusion Tensor Imaging and Fiber Tractography in Children with Craniosynostosis Syndromes.
Article in AJNR. American journal of neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Brain volume in infants with metopic synostosis: Less white matter volume with an accelerated growth pattern in early life.Journal of anatomy · 2024Article
- Neuroimaging in Nonsyndromic Craniosynostosis: Key Concepts to Unlock Innovation.Diagnostics (Basel, Switzerland) · 2024Review
- A diffusion tensor imaging comparison of white matter development in nonsyndromic craniosynostosis to neurotypical infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- A diffusion tensor imaging analysis of white matter microstructures in non-operated craniosynostosis patients.Neuroradiology · 2022Article
- Clinical staging of craniosynostosis: a call for investigation and collaboration.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Prenatal diagnosis of Pfeiffer syndrome type 2 with increased nuchal translucency.Clinical case reports · 2021Article
- Cortical Thickness in Crouzon-Pfeiffer Syndrome: Findings in Relation to Primary Cranial Vault Expansion.Plastic and reconstructive surgery. Global open · 2020Article
- Imaging in craniosynostosis: when and what?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
- A comparison of three fiber tract delineation methods and their impact on white matter analysis.NeuroImage · 2018Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposePatients with craniosynostosis syndromes caused by mutations in FGFR-2, FGFR-3, and TWIST1 genes are characterized by having prematurely fused skull sutures and skull base synchondroses, which result in a skull deformity and are accompanied by brain anomalies, including altered white matter microarchitecture. In this study, the reliability and reproducibility of DTI fiber tractography was investigated in these patients. The outcomes were compared with those of controls. MATERIALS AND
methodsDTI datasets were acquired with a 1.5T MR imaging system with 25 diffusion gradient orientations (voxel size = 1.8 × 1.8 × 3.0 mm(3), b-value = 1000 s/mm(2)). White matter tracts studied included the following: corpus callosum, cingulate gyrus, fornix, corticospinal tracts, and medial cerebellar peduncle. Tract pathways were reconstructed with ExploreDTI in 58 surgically treated patients with craniosynostosis syndromes and 7 controls (age range, 6-18 years).
resultsBecause of the brain deformity and abnormal ventricular shape and size, DTI fiber tractography was challenging to perform in patients with craniosynostosis syndromes. To provide reliable tracts, we adapted standard tracking protocols. Fractional anisotropy was equal to that in controls (0.44 versus 0.45 ± 0.02, P = .536), whereas mean, axial, and radial diffusivity parameters of the mean white matter were increased in patients with craniosynostosis syndromes (P < .001). No craniosynostosis syndrome-specific difference in DTI properties was seen for any of the fiber tracts studied in this work.
conclusionsPerforming DTI fiber tractography in patients with craniosynostosis syndromes was difficult due to partial volume effects caused by an anisotropic voxel size and deformed brain structures. Although these patients have a normal fiber organization, increased diffusivity parameters suggest abnormal microstructural tissue properties of the investigated white matter tracts.
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