ArticleNeuroImage2015
Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
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- Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model.Fluids and barriers of the CNS · 2022Article
- The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice.Scientific reports · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- Behavioral and physiological monitoring for awake neurovascular coupling experiments: a how-to guide.Neurophotonics · 2022Article
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- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Origins of 1/f-like tissue oxygenation fluctuations in the murine cortex.PLoS biology · 2021Article
- Iliski, a software for robust calculation of transfer functions.PLoS computational biology · 2021Article
- Gradual Not Sudden Change: Multiple Sites of Functional Transition Across the Microvascular Bed.Frontiers in aging neuroscience · 2021Article
- Cerebral amyloid angiopathy aggravates perivascular clearance impairment in an Alzheimer's disease mouse model.Acta neuropathologica communications · 2020Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Understanding the spatial dynamics of dilation in the cerebral vasculature is essential for deciphering the vascular basis of hemodynamic signals in the brain. We used two-photon microscopy to image neural activity and vascular dynamics in the somatosensory cortex of awake behaving mice during voluntary locomotion. Arterial dilations within the histologically-defined forelimb/hindlimb (FL/HL) representation were larger than arterial dilations in the somatosensory cortex immediately outside the FL/HL representation, demonstrating that the vascular response during natural behaviors was spatially localized. Surprisingly, we found that locomotion drove dilations in surface vessels that were nearly three times the amplitude of intracortical vessel dilations. The smaller dilations of the intracortical arterioles were not due to saturation of dilation. Anatomical imaging revealed that, unlike surface vessels, intracortical vessels were tightly enclosed by brain tissue. A mathematical model showed that mechanical restriction by the brain tissue surrounding intracortical vessels could account for the reduced amplitude of intracortical vessel dilation relative to surface vessels. Thus, under normal conditions, the mechanical properties of the brain may play an important role in sculpting the laminar differences of hemodynamic responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.