Evidence map›Paper›PMID 25953309›Full record

ArticleInternational journal of hematology2015

Epstein-Barr virus-positive diffuse large B-cell lymphoma following acute myeloid leukemia: a common clonal origin indicated by chromosomal translocation t(3;4)(p25;q21).

Masakazu Higuchi, Shoichi Sasaki, Shin-Ichiro Kawadoko, Hikaru Uchiyama, Takaharu Yasui, Takashi Kamihira, Ken-Ichi Aoki, Takakazu Sasaguri, Ryuji Nakano, Akihiko Uchiyama and 2 more

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In one paragraph

Article in International journal of hematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Masakazu HiguchiDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan. m.higuchi@jrkyushu-hospital.jp.
Shoichi SasakiDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan.
Shin-Ichiro KawadokoDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan.
Hikaru UchiyamaDepartment of Surgery, JCHO Kyushu Hospital, Fukuoka, Japan.
Takaharu YasuiDepartment of Surgery, JCHO Kyushu Hospital, Fukuoka, Japan.
Takashi KamihiraDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan.
Ken-Ichi AokiDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan.
Takakazu SasaguriDepartment of Pathology, JCHO Kyushu Hospital, Fukuoka, Japan.
Ryuji NakanoDepartment of Pathology, JCHO Kyushu Hospital, Fukuoka, Japan.
Akihiko UchiyamaDepartment of Surgery, JCHO Kyushu Hospital, Fukuoka, Japan.
Tsuyoshi MutaDepartment of Internal Medicine, Japan Community Health Care Organization (JCHO) Kyushu Hospital, Fukuoka, Japan.
Koichi OhshimaDepartment of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
Kyushu Hospital · JPKurume University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secondary non-Hodgkin lymphoma following acute myeloid leukemia (AML) is extremely rare. We here describe a unique case involving a patient who developed Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) during complete remission (CR) of AML. A 75-year-old Japanese man was initially diagnosed with AML with maturation (FAB M2), bearing chromosomal translocation t(3,4)(p25;q21). After intensive chemotherapy, bone marrow aspiration revealed normal karyotype, and he achieved CR. Six years and 4 months later, he was still in CR from AML, but developed DLBCL presenting in the terminal ileum. Cytogenetic analysis of the DLBCL cells showed the same translocation as the previous AML. The rearrangements of the immunoglobulin heavy chain genes of the two malignancies were examined using polymerase chain reaction amplification, and the rearrangement patterns were found to differ from each other. Our data thus suggest that, in the present case, the AML and DLBCL arose from a common progenitor cell, as indicated by the clonal abnormality t(3,4)(p25;q21), and that different immunoglobulin heavy chain gene rearrangements occurred during each course of clonal evolution.

Indexed as

Herpesvirus 4, HumanTranslocation, GeneticAgedChromosomes, Human, Pair 3Chromosomes, Human, Pair 4Epstein-Barr Virus InfectionsHumansLeukemia, Myeloid, AcuteLymphoma, Large B-Cell, DiffuseMaleNeoplasms, Second PrimaryAcute myeloid leukemiaClonalityDiffuse large B-cell lymphomaEpstein–Barr virusImmunoglobulin heavy chain

Identifiers

PMID25953309
OpenAlexW253205281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.