ArticleInternational journal of hematology2015
Kinetics of hematogones in bone marrow samples from patients with non-Hodgkin lymphomas treated with rituximab-containing regimens: a flow cytometric study.
Article in International journal of hematology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Baseline immunoglobulin G and immune function in non-Hodgkin lymphoma: a retrospective analysis.Frontiers in immunology · 2024Article
- The impact of anti-CD20-based therapy on hypogammaglobulinemia in patients with follicular lymphoma.Leukemia & lymphoma · 2022Article
- Hematogones in patients with acute myeloid leukaemia: Prognostic value and correlation with minimal residual disease.Leukemia research reports · 2021Article
- Abnormal B-cell maturation in the bone marrow of patients with germline mutations in PIK3CD.The Journal of allergy and clinical immunology · 2017Article
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Authors and funding
9 authors at 1 institution in 2 countries.
Funding
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Abstract
Treatment with rituximab, either alone or in combination with antiblastic drugs, causes significant depletion of circulating B-lymphocytes and modifications of B cell maturation in the bone marrow. In the present study, we analyzed the kinetics of hematogones in bone marrow samples from 55 patients suffering from non-Hodgkin lymphomas and treated with rituximab-containing regimens. Maturation arrest at the level of stage 2 hematogones, along with complete depletion of naïve, mature B-lymphocytes, was observed as short-term effects (2 months after completion of chemo-immunotherapy). Further bone marrow samples, obtained 12 months after the last rituximab infusion in 21 patients undergoing long-term follow-up and treated with rituximab maintenance therapy, showed complete normalization of B-lymphocyte ontogeny. Hypogammaglobulinemia developed in 26 patients, and was still observed in nine of the 21 patients undergoing long-term follow-up. Our study provides novel data on hematogone kinetics in the setting of patients with non-Hodgkin lymphomas treated with chemo-immunotherapy containing rituximab and with rituximab maintenance. Our observations show that hypogammaglobulinemia can persist in a significant percentage of patients, despite complete recovery of B-lymphocyte ontogeny.
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