ArticleDevelopmental cognitive neuroscience2015
Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood.
Article in Developmental cognitive neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- How adolescent cannabis use reshapes the developing brain - a systematic review.Frontiers in psychiatry · 2026Pooled it
- Systematic review of structural and functional neuroimaging studies of cannabis use in adolescence and emerging adulthood: evidence from 90 studies and 9441 participants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Pooled it
- Age- and Sex-Related Cortical Gray Matter Volume Differences in Adolescent Cannabis Users: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in psychiatry · 2021Pooled it
- A multi-site proof-of-concept investigation of computerized approach-avoidance training in adolescent cannabis users.Drug and alcohol dependence · 2018Trial
- Independent brain cortical signatures of risk for adolescent cannabis use and consequences of such use are moderated by sex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Abnormal Cortical Thickness Development in Young Adults With Heavy Cannabis Use: A Longitudinal Study.Addiction biology · 2025Article
- White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis.Translational psychiatry · 2024Article
- Adolescent substance use initiation and long-term neurobiological outcomes: insights, challenges and opportunities.Molecular psychiatry · 2024Review
- Macroscopic and Microscopic Cerebral Findings in Drug and Alcohol Abusers: The Point of View of the Forensic Pathologist.Biomedicines · 2024Review
- The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults.Brain sciences · 2024Article
- Abnormal developmental of structural covariance networks in young adults with heavy cannabis use: a 3-year follow-up study.Translational psychiatry · 2024Article
- Drugs, Guts, Brains, but Not Rock and Roll: The Need to Consider the Role of Gut Microbiota in Contemporary Mental Health and Wellness of Emerging Adults.International journal of molecular sciences · 2022Review
- Sex moderates effects of alcohol and cannabis co-use on alcohol and stress reactivity.Alcoholism, clinical and experimental research · 2022Article
- Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us.Alcohol research : current reviews · 2022Review
- The Effects of Alcohol and Cannabis Co-Use on Neurocognitive Function, Brain Structure, and Brain Function.Current behavioral neuroscience reports · 2021Article
- Association of Cannabis Use During Adolescence With Neurodevelopment.JAMA psychiatry · 2021Article
- Neuroimaging markers of adolescent depression in the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) study.Journal of affective disorders · 2021Article
- Sex and dependence related neuroanatomical differences in regular cannabis users: findings from the ENIGMA Addiction Working Group.Translational psychiatry · 2021Article
- Testing the association between tobacco and cannabis use and cognitive functioning: Findings from an observational and Mendelian randomization study.Drug and alcohol dependence · 2021Article
- Alcohol and Cannabis Use and the Developing Brain.Alcohol research : current reviews · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Studies suggest marijuana impacts gray and white matter neural tissue development, however few prospective studies have determined the relationship between cortical thickness and cannabis use spanning adolescence to young adulthood. This study aimed to understand how heavy marijuana use influences cortical thickness trajectories across adolescence. Subjects were adolescents with heavy marijuana use and concomitant alcohol use (MJ+ALC, n=30) and controls (CON, n=38) with limited substance use histories. Participants underwent magnetic resonance imaging and comprehensive substance use assessment at three independent time points. Repeated measures analysis of covariance was used to look at main effects of group, time, and Group × Time interactions on cortical thickness. MJ+ALC showed thicker cortical estimates across the brain (23 regions), particularly in frontal and parietal lobes (ps<.05). More cumulative marijuana use was associated with increased thickness estimates by 3-year follow-up (ps<.05). Heavy marijuana use during adolescence and into young adulthood may be associated with altered neural tissue development and interference with neuromaturation that can have neurobehavioral consequences. Continued follow-up of adolescent marijuana users will help understand ongoing neural changes that are associated with development of problematic use into adulthood, as well as potential for neural recovery with cessation of use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.