ArticlePlant physiology2015
Transcription Factor ATAF1 in Arabidopsis Promotes Senescence by Direct Regulation of Key Chloroplast Maintenance and Senescence Transcriptional Cascades.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.
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107 citing papers in PubMed, 215 citations in OpenAlex.
- The old nourishes the new: 100 years of leaf senescence studies in Plant Physiology.Plant physiology · 2026Review
- The plant longevity gene AHL15 delays leaf senescence by repressing ORESARA1 and cytokinin degradation.The Plant journal : for cell and molecular biology · 2026Article
- Genome‑Wide Identification of NAC Transcription Factors in Elymus sibiricus and Functional Characterisation of EsNAC29 in Light Inhibition.Plant, cell & environment · 2026Article
- SnRK2.4 and SnRK2.10 redundantly control developmental leaf senescence by sustaining ABA production and signaling.Plant physiology · 2026Article
- Gene network analysis predicts the primary regulators of ABA-dependent transcriptional activation and repression in Populus roots.PLoS genetics · 2026Article
- Regulatory Network of Leaf Senescence inInternational journal of molecular sciences · 2026Review
- DIVARICATA1 Promotes Leaf Degreening and Senescence in Arabidopsis.Plants (Basel, Switzerland) · 2026Article
- Identification of a new male sterile gene BrATAF1 of Chinese cabbage.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Expression of a constitutively active nitrate reductase increases SARS-CoV-2 Spike protein production in Nicotiana benthamiana leaves that otherwise show traits of senescence.Plant biotechnology journal · 2026Article
- The NAC Transcription FactorsInternational journal of molecular sciences · 2025Article
- Analysis of mechanisms underlying accelerated plant growth induced by NtGLK85 overexpression in tobacco.Scientific reports · 2025Article
- Genome-wide identification of NAC transcription factors in Acer paxii, and their expression dynamics during leaf aging.Genes & genomics · 2025Article
- NAC047/052/104 Synergistically Regulate the Dark-Induced Leaf Senescence in Non-Heading Chinese Cabbage.International journal of molecular sciences · 2025Article
- Overexpression of plasma membrane SUT1 in poplar alters lateral sucrose partitioning in stem and promotes leaf necrosis.Plant direct · 2025Article
- Article
- Modification of xylan in secondary walls alters cell wall biosynthesis and wood formation programs and improves saccharification.Plant biotechnology journal · 2025Article
- Identification of a Novel GeneInternational journal of molecular sciences · 2024Article
- Arabidopsis apoplast TET8 positively correlates to leaf senescence, andPlant direct · 2024Article
- Overexpression of RPOTmp Being Targeted to Either Mitochondria or Chloroplasts inInternational journal of molecular sciences · 2024Article
- Seasonal switching of integrated leaf senescence controls in an evergreen perennial Arabidopsis.Nature communications · 2024Article
47 more citing papers are in PubMed but not listed here.
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4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senescence represents a fundamental process of late leaf development. Transcription factors (TFs) play an important role for expression reprogramming during senescence; however, the gene regulatory networks through which they exert their functions, and their physiological integration, are still largely unknown. Here, we identify the Arabidopsis (Arabidopsis thaliana) abscisic acid (ABA)- and hydrogen peroxide-activated TF Arabidopsis thaliana activating factor1 (ATAF1) as a novel upstream regulator of senescence. ATAF1 executes its physiological role by affecting both key chloroplast maintenance and senescence-promoting TFs, namely GOLDEN2-LIKE1 (GLK1) and ORESARA1 (Arabidopsis NAC092), respectively. Notably, while ATAF1 activates ORESARA1, it represses GLK1 expression by directly binding to their promoters, thereby generating a transcriptional output that shifts the physiological balance toward the progression of senescence. We furthermore demonstrate a key role of ATAF1 for ABA- and hydrogen peroxide-induced senescence, in accordance with a direct regulatory effect on ABA homeostasis genes, including nine-CIS-epoxycarotenoid dioxygenase3 involved in ABA biosynthesis and ABC transporter G family member40, encoding an ABA transport protein. Thus, ATAF1 serves as a core transcriptional activator of senescence by coupling stress-related signaling with photosynthesis- and senescence-related transcriptional cascades.
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