Evidence map›Paper›PMID 25953057›Full record

ArticleBrain imaging and behavior2016

Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.

John D Eicher, Angela M Montgomery, Natacha Akshoomoff, David G Amaral, Cinnamon S Bloss, Ondrej Libiger, Nicholas J Schork, Burcu F Darst, B J Casey, Linda Chang and 17 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  8. Brain structure and neural activity related to reading in boys with isolated oral clefts.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 9 institutions in 3 countries.

John D EicherDepartment of Genetics, Yale University, New Haven, CT, 06520, USA.
Angela M MontgomeryDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA.
Natacha AkshoomoffCenter for Human Development, University of California, La Jolla, San Diego, CA, 92037, USA.
David G AmaralDepartment of Psychiatry and Behavioral Sciences, University of California, Davis, CA, 95817, USA.
Cinnamon S BlossScripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, La Jolla, CA, 92037, USA.
Ondrej LibigerScripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, La Jolla, CA, 92037, USA.
Nicholas J SchorkScripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, La Jolla, CA, 92037, USA.
Burcu F DarstScripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, La Jolla, CA, 92037, USA.
B J CaseySackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY, 10065, USA.
Linda ChangDepartment of Medicine, Queen's Medical Center, University of Hawaii, Honolulu, HI, 96813, USA.
Thomas ErnstDepartment of Medicine, Queen's Medical Center, University of Hawaii, Honolulu, HI, 96813, USA.
Jean FrazierDepartment of Psychiatry, University of Massachusetts Medical School, Boston, MA, 01655, USA.
Walter E KaufmannKennedy Krieger Institute, 707 N. Broadway, Baltimore, MD, 21205, USA.
Brian KeatingDepartment of Medicine, Queen's Medical Center, University of Hawaii, Honolulu, HI, 96813, USA.
Tal KenetDepartment of Neurology and Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
David KennedyDepartment of Psychiatry, University of Massachusetts Medical School, Boston, MA, 01655, USA.
Stewart MostofskyKennedy Krieger Institute, 707 N. Broadway, Baltimore, MD, 21205, USA.
Sarah S MurrayScripps Genomic Medicine, Scripps Health, Scripps Translational Science Institute, La Jolla, CA, 92037, USA.
Elizabeth R SowellDepartment of Pediatrics, University of Southern California, Los Angeles, CA, 90027, USA.
Hauke BartschMultimodal Imaging Laboratory, University of California, La Jolla, San Diego, CA, 92037, USA.
Joshua M KupermanMultimodal Imaging Laboratory, University of California, La Jolla, San Diego, CA, 92037, USA.
Timothy T BrownCenter for Human Development, University of California, La Jolla, San Diego, CA, 92037, USA.
Donald J HaglerMultimodal Imaging Laboratory, University of California, La Jolla, San Diego, CA, 92037, USA.
Anders M DaleDepartment of Psychiatry, University of California, La Jolla, San Diego, CA, 92037, USA.
Terry L JerniganCenter for Human Development, University of California, La Jolla, San Diego, CA, 92037, USA.
Jeffrey R GruenDepartment of Genetics, Yale University, New Haven, CT, 06520, USA. jeffrey.gruen@yale.edu.
Pediatric Imaging Neurocognition Genetics Study
University of California System · USScripps Research Institute · USYale University · USKennedy Krieger Institute · USUniversity of Hawaii System · USUniversity of Massachusetts Chan Medical School · USUniversity of Southern California · USBoston Children's Hospital · USMassachusetts General Hospital · US

Funding

VALIDITY OF SUBTYPES OF ADHDP50HD027802 · NICHD · UNIVERSITY OF COLORADO AT BOULDER · PI ERIK G WILLCUTT · 1990 to 2026
$44.9M
Skill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0M
Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
TISSUE CULTURE CORE FACILITYP30HD004147 · NICHD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KENNEDY, DAVID NELSON · 1985 to 2014
$9.1M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI · 2014 to 2019
$7.9M
Exposing the Deep Content of the Publication: Knowledge Extraction for Neuroimaging in Child PsychiatryR01MH083320 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FRAZIER, JEAN A, KENNEDY, DAVID NELSON · 2009 to 2020
$6.3M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
Discovery of the 6p21.3 Reading Disability GeneR01NS043530 · NINDS · YALE UNIVERSITY · PI GRUEN, JEFFREY R · 2003 to 2010
$4.3M
RESEARCH IN PERINATAL MEDICINET32HD007094 · NICHD · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 1985 to 2015
$3.6M
Pleiotropic Roles of Dyslexia Genes in Neurodevelopmental Language ImpairmentsF31DC012270 · NIDCD · YALE UNIVERSITY · PI EICHER, JOHN · 2011 to 2013
$121k
NICHD NIH HHS 2P50 HD 027802-22NICHD NIH HHS P30 HD004147NICHD NIH HHS P50 HD027802NICHD NIH HHS T32 HD007094NICHD NIH HHS T32 HD07094NICHD NIH HHS U54 HD079123NICHD NIH HHS U54 HD090255NIDA NIH HHS RC2 DA029475NIDA NIH HHS RC2DA029475NIDCD NIH HHS F31 DC012270NIDCD NIH HHS F31DC012270NIGMS NIH HHS T32 GM007223NIMH NIH HHS R01 MH083320NINDS NIH HHS R01 NS043530
6 · The paper itself

Abstract

Dyslexia and language impairment (LI) are complex traits with substantial genetic components. We recently completed an association scan of the DYX2 locus, where we observed associations of markers in DCDC2, KIAA0319, ACOT13, and FAM65B with reading-, language-, and IQ-related traits. Additionally, the effects of reading-associated DYX3 markers were recently characterized using structural neuroimaging techniques. Here, we assessed the neuroimaging implications of associated DYX2 and DYX3 markers, using cortical volume, cortical thickness, and fractional anisotropy. To accomplish this, we examined eight DYX2 and three DYX3 markers in 332 subjects in the Pediatrics Imaging Neurocognition Genetics study. Imaging-genetic associations were examined by multiple linear regression, testing for influence of genotype on neuroimaging. Markers in DYX2 genes KIAA0319 and FAM65B were associated with cortical thickness in the left orbitofrontal region and global fractional anisotropy, respectively. KIAA0319 and ACOT13 were suggestively associated with overall fractional anisotropy and left pars opercularis cortical thickness, respectively. DYX3 markers showed suggestive associations with cortical thickness and volume measures in temporal regions. Notably, we did not replicate association of DYX3 markers with hippocampal measures. In summary, we performed a neuroimaging follow-up of reading-, language-, and IQ-associated DYX2 and DYX3 markers. DYX2 associations with cortical thickness may reflect variations in their role in neuronal migration. Furthermore, our findings complement gene expression and imaging studies implicating DYX3 markers in temporal regions. These studies offer insight into where and how DYX2 and DYX3 risk variants may influence neuroimaging traits. Future studies should further connect the pathways to risk variants associated with neuroimaging/neurocognitive outcomes.

Indexed as

Genetic Predisposition to DiseaseAdolescentBrainCell Adhesion MoleculesChildChild, PreschoolCohort StudiesCross-Sectional StudiesDiffusion Magnetic Resonance ImagingDiffusion Tensor ImagingDyslexiaGenotyping TechniquesHumansLanguage Development DisordersNerve Tissue ProteinsOrgan SizeACOT13 protein, humanCell Adhesion MoleculesKIAA0319 protein, humanNerve Tissue ProteinsProteinsRIPOR2 protein, humanThiolester HydrolasesDyslexiaDYX2DYX3Imaging-geneticsKIAA0319Language impairment

Identifiers

PMID25953057
PMCPMC4639472
OpenAlexW247387576

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.