Evidence map›Paper›PMID 25953000›Full record

ArticleEuropean radiology2015

Lung cancer risk and cancer-specific mortality in subjects undergoing routine imaging test when stratified with and without identified lung nodule on imaging study.

Noemi Gómez-Sáez, Ildefonso Hernández-Aguado, José Vilar, Isabel González-Alvarez, María Fermina Lorente, María Luisa Domingo, María Pastor Valero, Lucy Anne Parker, Blanca Lumbreras

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In one paragraph

Article in European radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules.Clinical cancer research : an official journal of the American Association for Cancer Research · 2017
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Noemi Gómez-SáezPublic Health, History of Science and Ginecology Department, Miguel Hernández University, Alicante, Spain.
Ildefonso Hernández-AguadoPublic Health, History of Science and Ginecology Department, Miguel Hernández University, Alicante, Spain.
José VilarRadiodiagnostic Department, Peset Hospital, Valencia, Spain.
Isabel González-AlvarezRadiodiagnostic Department, San Juan Hospital, San Juan de Alicante, Spain.
María Fermina LorenteRadiodiagnostic Department, San Juan Hospital, San Juan de Alicante, Spain.
María Luisa DomingoRadiodiagnostic Department, Peset Hospital, Valencia, Spain.
María Pastor ValeroPublic Health, History of Science and Ginecology Department, Miguel Hernández University, Alicante, Spain.
Lucy Anne ParkerPublic Health, History of Science and Ginecology Department, Miguel Hernández University, Alicante, Spain.
Blanca LumbrerasPublic Health, History of Science and Ginecology Department, Miguel Hernández University, Alicante, Spain. blumbreras@umh.es.
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública · ESHospital Universitario Doctor Peset · ESHospital Universitari Sant Joan D'Alacant · ESUniversitat de Miguel Hernández d'Elx · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the risk of lung cancer and specific mortality rate in patients with and without solitary pulmonary nodules (SPN) on chest radiograph and CT.

methodsThis prospective study included 16,078 patients ≥35 years old (893 of them had an SPN detected with either chest radiograph or CT) and 15,185 without SPN. Patients were followed up for 18 months or until being diagnosed with lung cancer. Risk and mortality lung cancer were calculated in both groups with Poisson regression.

resultsIn patients with SPN, incidence of lung cancer was 8.3 % (95 % CI 6.0-11.2) on radiograph and 12.4 % (95 % CI 9.3-15.9) on CT. A chronic obstructive pulmonary disease in patients with radiographs (odds ratio 2.62; 95 % CI 1.03, 6.67) and smoking habit (odds ratio 20.63; 95 % CI 3.84, 110.77) in patients with CT were associated with a higher probability of lung cancer. Large nodule size and spiculated edge were associated with lung cancer on both CT and radiograph. Lung cancer-specific mortality was lower in patients with SPN than in those without SPN (1.73/1000 person-years, 95 % CI 1.08-2.88 vs. 2.15/1000 person-years, 95 % CI 1.25-3.96).

conclusionsThe risk of lung cancer for patients with SPN is higher in clinical populations than in screening studies. Moreover, patients with SPN showed lower mortality than those without SPN. KEY POINTS: • Lung cancer risk is 8 % for SPN detected on routine radiographs. • Lung cancer risk is 12.4 % for SPN detected in routine chest CT. • Smoking, COPD, SPN diameter and edge were predictors of malignancy. • Lung cancer risk of SPN in routine practice seems higher than in screening.

Indexed as

AgedCohort StudiesComorbidityFemaleFollow-Up StudiesHumansIncidenceLungLung NeoplasmsMaleMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructiveRiskSmokingSolitary Pulmonary NoduleDiagnostic imagingGeneral populationLung neoplasmMortalitySolitary pulmonary nodule (SPN)

Identifiers

PMID25953000
OpenAlexW2196814937

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.