ReviewDepression and anxiety2015
DISSECTING OCD CIRCUITS: FROM ANIMAL MODELS TO TARGETED TREATMENTS.
Review in Depression and anxiety, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 5 syntheses or guidelines pooled it, 126 citations in OpenAlex.
- The Efficacy of Transcranial Magnetic Stimulation in the Treatment of Obsessive-Compulsive Disorder: An Umbrella Review of Meta-Analyses.CNS spectrums · 2024Pooled it
- Fear conditioning and extinction in obsessive-compulsive disorder: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021Pooled it
- Transcranial magnetic stimulation of the medial prefrontal cortex for psychiatric disorders: a systematic review.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2019Pooled it
- A systematic review of the neural bases of psychotherapy for anxiety and related disorders.Dialogues in clinical neuroscience · 2015Pooled it
- Treating refractory obsessive-compulsive disorder with transcranial direct current stimulation: An open label study.Brain and behavior · 2020Trial
- Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.bioRxiv : the preprint server for biology · 2026Article
- Multimodal network localization of brain abnormalities and neuromodulation target identification in obsessive-compulsive disorder.Scientific reports · 2026Article
- Mapping the brain atrophy mediating increased impatience for reward in frontotemporal dementia.Communications biology · 2026Article
- From lesion to circuit modulation: A narrative review of psychosurgery in refractory obsessive-compulsive disorder, treatment-resistant depression, and pathological aggression.Surgical neurology international · 2026Review
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- Circuit-based neuromodulation for obsessive-compulsive disorder: a review of prior and emerging methods.Frontiers in psychiatry · 2026Review
- High Doses of Antidepressants and Long-term Treatment of Obsessive-compulsive Disorder: Another Barrier to Accessing Deep Brain Stimulation?Alpha psychiatry · 2025Article
- Inhibition of TRPM3 channels in the medial prefrontal cortex mitigates OCD symptoms following traumatic brain injury.Inflammopharmacology · 2025Article
- Augmentative transcranial magnetic stimulation over the left orbitofrontal cortex in patients with treatment-resistant obsessive-compulsive disorder: An acute and follow-up study.Neuroscience applied · 2025Article
- Neurobiology of Obsessive-Compulsive Disorder from Genes to Circuits: Insights from Animal Models.Neuroscience bulletin · 2024Review
- Brain-computer interfaces for neuropsychiatric disorders.Nature reviews bioengineering · 2024Article
- Neural substrates for regulating self-grooming behavior in rodents.Journal of Zhejiang University. Science. B · 2024Review
- Hyperactivity of indirect pathway-projecting spiny projection neurons promotes compulsive behavior.Nature communications · 2024Article
- Beyond Diagnosis: Preliminary Study of Impact on Children and Parents in Neurodevelopmental Disorders and Juvenile Idiopathic Arthritis-Associated Uveitis.Diagnostics (Basel, Switzerland) · 2024Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Obsessive-compulsive disorder (OCD) is a chronic, severe mental illness with up to 2-3% prevalence worldwide. In fact, OCD has been classified as one of the world's 10 leading causes of illness-related disability according to the World Health Organization, largely because of the chronic nature of disabling symptoms.([1]) Despite the severity and high prevalence of this chronic and disabling disorder, there is still relatively limited understanding of its pathophysiology. However, this is now rapidly changing due to development of powerful technologies that can be used to dissect the neural circuits underlying pathologic behaviors. In this article, we describe recent technical advances that have allowed neuroscientists to start identifying the circuits underlying complex repetitive behaviors using animal model systems. In addition, we review current surgical and stimulation-based treatments for OCD that target circuit dysfunction. Finally, we discuss how findings from animal models may be applied in the clinical arena to help inform and refine targeted brain stimulation-based treatment approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.