Evidence map›Paper›PMID 25952936›Full record

ArticlePhysiological reports2015

Ischemic preconditioning accelerates muscle deoxygenation dynamics and enhances exercise endurance during the work-to-work test.

Kohei Kido, Tadashi Suga, Daichi Tanaka, Toyoyuki Honjo, Toshiyuki Homma, Satoshi Fujita, Takafumi Hamaoka, Tadao Isaka

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  12. Effects of ischemic preconditioning on economy, VOEuropean journal of applied physiology · 2018
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  14. No influence of ischemic preconditioning on running economy.European journal of applied physiology · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kohei KidoFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Tadashi SugaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan t-suga@fc.ritsumei.ac.jp.
Daichi TanakaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Toyoyuki HonjoFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Toshiyuki HommaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Satoshi FujitaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Takafumi HamaokaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.
Tadao IsakaFaculty of Sport and Health Science, Ritsumeikan University, Kusatsu, Shiga, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ischemic preconditioning (IPC) improves maximal exercise performance. However, the potential mechanism(s) underlying the beneficial effects of IPC remain unknown. The dynamics of pulmonary oxygen uptake (VO2) and muscle deoxygenation during exercise is frequently used for assessing O2 supply and extraction. Thus, this study examined the effects of IPC on systemic and local O2 dynamics during the incremental step transitions from low- to moderate- and from moderate- to severe-intensity exercise. Fifteen healthy, male subjects were instructed to perform the work-to-work cycling exercise test, which was preceded by the control (no occlusion) or IPC (3 × 5 min, bilateral leg occlusion at >300 mmHg) treatments. The work-to-work test was performed by gradually increasing the exercise intensity as follows: low intensity at 30 W for 3 min, moderate intensity at 90% of the gas exchange threshold (GET) for 4 min, and severe intensity at 70% of the difference between the GET and VO2 peak until exhaustion. During the exercise test, the breath-by-breath pulmonary VO2 and near-infrared spectroscopy-derived muscle deoxygenation were continuously recorded. Exercise endurance during severe-intensity exercise was significantly enhanced by IPC. There were no significant differences in pulmonary VO2 dynamics between treatments. In contrast, muscle deoxygenation dynamics in the step transition from low- to moderate-intensity was significantly faster in IPC than in CON (27.2 ± 2.9 vs. 19.8 ± 0.9 sec, P < 0.05). The present findings showed that IPC accelerated muscle deoxygenation dynamics in moderate-intensity exercise and enhanced severe-intensity exercise endurance during work-to-work test. The IPC-induced effects may result from mitochondrial activation in skeletal muscle, as indicated by the accelerated O2 extraction.

Indexed as

Exercisemitochondrianear‐infrared spectroscopynitric oxideskeletal muscle

Identifiers

PMID25952936
PMCPMC4463825

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.