ArticleJournal of translational medicine2015
DNA methylation analysis of phenotype specific stratified Indian population.
Article in Journal of translational medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A scoping review of clinicalFrontiers in medicine · 2026Pooled it
- Predicting susceptibility to inflammaging using a genetic inflammatory index through Prakriti-based phenotypic stratification.Frontiers in immunology · 2026Article
- Prakriti (constitutional typology) in Ayurveda: a critical review of Prakriti assessment tools and their scientific validity.Frontiers in medicine · 2025Review
- Unravelling the gut-lung axis: insights into microbiome interactions and Traditional Indian Medicine's perspective on optimal health.FEMS microbiology ecology · 2023Review
- Ayurgenomics-based frameworks in precision and integrative medicine: Translational opportunities.Cambridge prisms. Precision medicine · 2023Review
- Whole Exome Sequencing in Healthy Individuals of Extreme Constitution Types Reveals Differential Disease Risk: A Novel Approach towards Predictive Medicine.Journal of personalized medicine · 2022Article
- An Ayurgenomics Approach: Prakriti-Based Drug Discovery and Development for Personalized Care.Frontiers in pharmacology · 2022Review
- Baseline cell proliferation rates and response to UV differ in lymphoblastoid cell lines derived from healthy individuals of extreme constitution types.Cell cycle (Georgetown, Tex.) · 2021Article
- Ayurgenomics and Modern Medicine.Medicina (Kaunas, Lithuania) · 2020Review
- Comparative gut microbiome analysis of the3 Biotech · 2020Article
- Functional signature analysis of extreme Prakriti endophenotypes in gut microbiome of western Indian rural population.Bioinformation · 2019Article
- Gene promoter-associated CpG island hypermethylation in squamous cell carcinoma of the tongue.Virchows Archiv : an international journal of pathology · 2017Article
- DNA methylation-based variation between human populations.Molecular genetics and genomics : MGG · 2017Review
- A glimpse of Ayurveda - The forgotten history and principles of Indian traditional medicine.Journal of traditional and complementary medicine · 2017Review
- Recapitulation of Ayurveda constitution types by machine learning of phenotypic traits.PloS one · 2017Article
- Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum.PloS one · 2017Article
- Epigenetic Mechanisms of Integrative Medicine.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Genome-wide analysis correlates Ayurveda Prakriti.Scientific reports · 2015Article
- Integrating ayurvedic medicine into cancer research programs part 1: Ayurveda background and applications.Journal of Ayurveda and integrative medicineReview
- Using Traditional Typologies to Understand Posture Movement and Cognitive Performance - A cross sectional study.International journal of yogaArticle
Corrections and comments
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Authors and funding
24 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDNA methylation and its perturbations are an established attribute to a wide spectrum of phenotypic variations and disease conditions. Indian traditional system practices personalized medicine through indigenous concept of distinctly descriptive physiological, psychological and anatomical features known as prakriti. Here we attempted to establish DNA methylation differences in these three prakriti phenotypes.
methodsFollowing structured and objective measurement of 3416 subjects, whole blood DNA of 147 healthy male individuals belonging to defined prakriti (Vata, Pitta and Kapha) between the age group of 20-30years were subjected to methylated DNA immunoprecipitation (MeDIP) and microarray analysis. After data analysis, prakriti specific signatures were validated through bisulfite DNA sequencing.
resultsDifferentially methylated regions in CpG islands and shores were significantly enriched in promoters/UTRs and gene body regions. Phenotypes characterized by higher metabolism (Pitta prakriti) in individuals showed distinct promoter (34) and gene body methylation (204), followed by Vata prakriti which correlates to motion showed DNA methylation in 52 promoters and 139 CpG islands and finally individuals with structural attributes (Kapha prakriti) with 23 and 19 promoters and CpG islands respectively. Bisulfite DNA sequencing of prakriti specific multiple CpG sites in promoters and 5'-UTR such as; LHX1 (Vata prakriti), SOX11 (Pitta prakriti) and CDH22 (Kapha prakriti) were validated. Kapha prakriti specific CDH22 5'-UTR CpG methylation was also found to be associated with higher body mass index (BMI).
conclusionDifferential DNA methylation signatures in three distinct prakriti phenotypes demonstrate the epigenetic basis of Indian traditional human classification which may have relevance to personalized medicine.
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