ArticleBMC pulmonary medicine2015
Anemia and hemoglobin serum levels are associated with exercise capacity and quality of life in chronic obstructive pulmonary disease.
Article in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 68 citations in OpenAlex.
- The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Evaluation of Macitentan in Patients With Eisenmenger Syndrome.Circulation · 2019Trial
- Secondary polycythemia as a rare cause of ischemic stroke: A case report.Radiology case reports · 2026Article
- Exploring the link: nutritional status and chronic obstructive pulmonary disease - insights from NHANES and clinical research.BMC pulmonary medicine · 2025Article
- Age-differentiated comparison of health-related quality of life and impacting factors in patients with COPD receiving long-term home non-invasive ventilation.BMC pulmonary medicine · 2025Observational
- Longitudinal association between hemoglobin and lung function with insights into the incidence of airflow obstruction: an observational study.BMC pulmonary medicine · 2025Observational
- Predictors of static and dynamic balance control in kidney transplant recipients.Wiener klinische Wochenschrift · 2025Article
- Body Mass Index and Lung Function in Hospitalized Severe AECOPD Patients: Investigating Nonlinear Associations and the Role of Hemoglobin.International journal of chronic obstructive pulmonary disease · 2025Article
- Longitudinal anemia status and risk for adverse outcomes in former smokers with COPD.Respiratory research · 2024Article
- The treatment of chronic anemia in heart failure: a global approach.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Review
- Factors Associated with the Discrepancy between Exercise Capacity and Airflow Limitation in Patients with Chronic Obstructive Pulmonary Disease.Tuberculosis and respiratory diseases · 2024Article
- Extrapulmonary Comorbidities Associated with Chronic Obstructive Pulmonary Disease: A Review.International journal of chronic obstructive pulmonary disease · 2024Review
- Development of a prediction model for exercise tolerance decline in the exercise assessment of patients with acute myocardial infarction undergoing percutaneous coronary intervention revascularization in the acute phase.Journal of thoracic disease · 2023Article
- Hemoglobin level is negatively associated with sarcopenia and its components in Chinese aged 60 and above.Frontiers in public health · 2023Article
- Fatigue and Its Related Factors Among Iranian Cancer Survivors.Journal of caring sciences · 2021Article
- Polycythemia is Associated with Lower Incidence of Severe COPD Exacerbations in the SPIROMICS Study.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2021Article
- Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors.BMC pulmonary medicine · 2021Observational
- Haemoglobin as a biomarker for clinical outcomes in chronic obstructive pulmonary disease.ERJ open research · 2021Article
- Association between 6 min pegboard and ring test and arm performance in GOLD stage II-III patients.Wiener klinische Wochenschrift · 2021Article
- Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis.Cancers · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle is known about the relationship between hemoglobin concentrations, functional status and health related quality of life (HRQL) in chronic obstructive pulmonary disease (COPD). Our aim was to investigate the prevalence of anemia and the association of hemoglobin with shortness of breath, exercise capacity, muscle strength and HRQL, in COPD patients.
methodsA total of 105 COPD patients (77 males, 71.6 ± 9.2 years) were studied. Patients were classified as anemic and non anemic using the WHO criteria. We used the Medical Research Council Dyspnoea scale (MRCs) to measure shortness of breath. Exercise capacity was assessed using the six minute walking distance (6MWD) and the peak of VO2 during the maximal cycle ergometer test (VO2max). We used the Quadriceps and Handgrip strength assessment to determine muscle strength. The Saint George Respiratory Questionnaire was used to investigate HRQL. The physiological/functional characteristics of the two groups were compared. Regression models adjusting for confounders examined the independent association of anemia and of hemoglobin levels with clinical and functional outcomes.
resultsAnemic patients (12.3%) showed a significantly higher MRCs, a lower 6MWD, VO2max, and a worse quality of life. On the contrary, there was no difference in muscle strength between the two groups. In the regression models, hemoglobin was independently associated with reduced exercise capacity and HRQL.
conclusionsAnemia in COPD was a risk factor for poorer exercise capacity and quality of life, and these outcomes were linearly associated with hemoglobin. Our results should stimulate further research into exploring whether increasing hemoglobin has a beneficial effect on the outcomes in COPD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.