ArticleWorld journal of surgery2015
Comorbidities and Risk of Complications After Surgery for Esophageal Cancer: A Nationwide Cohort Study in Sweden.
Article in World journal of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Ivor Lewis minimally invasive oesophagectomy versus McKeown approach: short-term benefits and mid-term equivalence in a randomized trial for oesophageal squamous cell carcinoma.Surgical endoscopy · 2026Trial
- Article
- Impact of the Charlson Comorbidity Index on the Short-Term and Long-Term Prognoses of Patients with Coronary Artery Disease Undergoing Percutaneous Coronary Intervention.Therapeutics and clinical risk management · 2026Article
- Nomographic predictive models for complications after minimally invasive esophagectomy: Current status and future perspectives.World journal of gastrointestinal surgery · 2025Review
- CRISPR/Cas9-Mediated CtBP1 Gene Editing Enhances Chemosensitivity and Inhibits Metastatic Potential in Esophageal Squamous Cell Carcinoma Cells.International journal of molecular sciences · 2023Article
- An Association Between Comorbidities and Postsurgical Complications in Adults Who Underwent Esophagectomy.Cureus · 2023Article
- Feasibility analysis of combined surgery for esophageal cancer.World journal of surgical oncology · 2023Article
- Feasibility study of adjuvant chemotherapy with S-1 after curative esophagectomy following neoadjuvant chemotherapy for esophageal cancer.BMC cancer · 2022Article
- The impact of skeletal muscle wasting during neoadjuvant chemotherapy on postoperative anastomotic leakage in patients with esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2021Article
- Impact of co-morbidity on reoperation or death within 90 days of surgery for oesophageal cancer.BJS open · 2021Article
- [Prognostic Risk Factors for Patients Receiving Airway Stent Placement].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2020Article
- The resistance of esophageal cancer cells to paclitaxel can be reduced by the knockdown of long noncoding RNA DDX11-AS1 through TAF1/TOP2A inhibition.American journal of cancer research · 2019Article
- The impact of the Charlson comorbidity index on the prognosis of esophageal cancer patients who underwent esophagectomy with curative intent.Surgery today · 2018Article
- Accuracy of co-morbidity data in patients undergoing abdominal wall hernia repair: a retrospective study.Hernia : the journal of hernias and abdominal wall surgery · 2018Article
- Observational
- Comparison of risk-scoring systems in the prediction of outcome after liver resection.Perioperative medicine (London, England) · 2017Article
- Perioperative outcomes of esophageal cancer surgery in a mid-volume institution in the era of centralization.Langenbeck's archives of surgery · 2016Article
- Effect of Comorbidity on Postoperative Survival Outcomes in Patients with Solid Cancers: A 6-Year Multicenter Study in Taiwan.Journal of Cancer · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe selection for surgery is multifaceted for patients diagnosed with esophageal cancer. Since it is uncertain how comorbidity should influence the selection, this study addressed comorbidities in relation to risk of severe complications following esophageal cancer surgery.
methodsThis population-based cohort study was based on prospectively included patients who underwent surgical resection for an esophageal or gastro-esophageal junctional cancer in Sweden during 2001-2005. The participation rate was 90%. Associations between pre-defined comorbidities and pre-defined post-operative complications occurring within 30 days of surgery were analyzed using multivariable logistic regression. The resulting odds ratios (ORs) and 95% confidence intervals (CIs) were adjusted for age, sex, tumor stage, tumor histology, neoadjuvant therapy, type of surgery, annual hospital volume, other comorbidities, and other complications.
resultsAmong 609 included patients, those with cardiac disease (n = 92) experienced an increased risk of pre-defined complications in general (adjusted OR 1.81, 95% CI 1.13-2.90), while patients with hypertension (n = 137), pulmonary disorders (n = 79), diabetes (n = 67), and obesity (n = 66) did not. Patients with a Charlson comorbidity index score ≥2 had substantially increased risks of pre-defined complications (adjusted OR 2.44, 95% CI 1.60-3.72).
conclusionCardiac disease and a Charlson comorbidity index score ≥2 seem to increase the risk of severe and early post-operative complications in patients with esophageal cancer, while hypertension, pulmonary disorders, diabetes, and obesity do not. These findings should be considered in the clinical decision-making for improved selection of patients for surgery.
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