ArticleJournal of vascular and interventional radiology : JVIR2015
Hemodynamic and Hematologic Effects of Histotripsy of Free-Flowing Blood: Implications for Ultrasound-Mediated Thrombolysis.
Article in Journal of vascular and interventional radiology : JVIR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Understanding histotripsy ablation safety: a systematic review of pre-clinical and clinical adverse events.CVIR oncology · 2026Review
- Assessment of Catheter-Directed Thrombolysis and Histotripsy Treatment for Deep Vein Thrombosis.Journal of vascular and interventional radiology : JVIR · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis.Research (Washington, D.C.) · 2023Article
- Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug.Journal of visualized experiments : JoVE · 2021Article
- Integrated Histotripsy and Bubble Coalescence Transducer for Rapid Tissue Ablation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2018Article
- Ultrasonic Cavitation-Enabled Treatment for Therapy of Hypertrophic Cardiomyopathy: Proof of Principle.Ultrasound in medicine & biology · 2018Article
- Catheter Hydrophone Aberration Correction for Transcranial Histotripsy Treatment of Intracerebral Hemorrhage: Proof-of-Concept.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Non-Invasive Thrombolysis Using Microtripsy in a Porcine Deep Vein Thrombosis Model.Ultrasound in medicine & biology · 2017Article
- Noninvasive thrombolysis using microtripsy: a parameter study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo investigate the extent and consequences of histotripsy-induced hemolysis in vivo. MATERIALS AND
methodsPorcine femoral venous blood was treated with histotripsy in 11 animals with systemic heparinization and 11 without heparin. Serum and hemodynamic measurements were obtained at 0, 2, 5, 10, 15, and 30 minutes and 48-72 hours after the procedure. Fisher exact test was used to determine differences in mortality between heparinized and nonheparinized groups. A linear mixed effects model was used to test for differences in blood analytes and hemodynamic variables over time.
resultsOf 11 animals in the nonheparinized group, 5 died during or immediately after histotripsy (45% nonheparin mortality vs 0% heparin mortality, P = .035). Serum hematocrit, free hemoglobin, lactate dehydrogenase (LDH), and right ventricular systolic pressure changed significantly (P < .001) over the treatment time. Serum hematocrit decreased slightly (from 32.5% ± 3.6% to 29.4% ± 4.2%), whereas increases were seen in free hemoglobin (from 6.2 mg/dL ± 4.6 to 348 mg/dL ± 100), LDH (from 365 U/L ± 67.8 ± to 722 U/L ± 84.7), and right ventricular systolic pressure (from 23.2 mm Hg ± 7.2 to 39.7 mm Hg ± 12.3). After 48-72 hours, hematocrit remained slightly decreased (P = .005), whereas LDH and free hemoglobin remained slightly increased compared with baseline (both P < .001).
conclusionsIntravascular histotripsy applied to free-flowing venous blood is safe with systemic heparinization, causing only transient hemodynamic and metabolic disturbances, supporting its use as a future noninvasive thrombolytic therapy modality.
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