ArticleDevelopmental biology2015
The endoderm and myocardium join forces to drive early heart tube assembly.
Article in Developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Coordination of cardiogenesis in vivo and in vitro.Nature reviews. Molecular cell biology · 2026Review
- The Congenital Malformation of the Interatrial Septum-A Review of Its Development and Embryology with Clinical Implications.Journal of developmental biology · 2025Review
- In Vitro Models of Cardiovascular Disease: Embryoid Bodies, Organoids and Everything in Between.Biomedicines · 2024Review
- Article
- A chemo-mechanical model of endoderm movements driving elongation of the amniote hindgut.bioRxiv : the preprint server for biology · 2023Article
- Quantifying endodermal strains during heart tube formation in the developing chicken embryo.Journal of biomechanics · 2023Article
- Graded mesoderm assembly governs cell fate and morphogenesis of the early mammalian heart.Cell · 2023Article
- The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation.bioRxiv : the preprint server for biology · 2023Article
- The ECM: To Scaffold, or Not to Scaffold, That Is the Question.International journal of molecular sciences · 2021Review
- Of form and function: Early cardiac morphogenesis across classical and emerging model systems.Seminars in cell & developmental biology · 2021Review
- The Chicken as a Model Organism to Study Heart Development.Cold Spring Harbor perspectives in biology · 2020Review
- Guiding Cell Network Assembly using Shape-Morphing Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Extracellular matrix dynamics in tubulogenesis.Cellular signalling · 2020Review
- Follow Me! A Tale of Avian Heart Development with Comparisons to Mammal Heart Development.Journal of cardiovascular development and disease · 2020Review
- Viscoelastic Properties of ECM-Rich Embryonic Microenvironments.Frontiers in cell and developmental biology · 2020Article
- Matrigel patterning reflects multicellular contractility.PLoS computational biology · 2019Article
- Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration.Nature communications · 2019Article
- The heart tube forms and elongates through dynamic cell rearrangement coordinated with foregut extension.Development (Cambridge, England) · 2018Article
- Single and collective cell migration: the mechanics of adhesions.Molecular biology of the cell · 2017Article
- A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction.Development (Cambridge, England) · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Formation of the muscular layer of the heart, the myocardium, involves the medial movement of bilateral progenitor fields; driven primarily by shortening of the endoderm during foregut formation. Using a combination of time-lapse imaging, microsurgical perturbations and computational modeling, we show that the speed of the medial-ward movement of the myocardial progenitors is similar, but not identical to that of the adjacent endoderm. Further, the extracellular matrix microenvironment separating the two germ layers also moves with the myocardium, indicating that collective tissue motion and not cell migration drives tubular heart assembly. Importantly, as myocardial cells approach the midline, they perform distinct anterior-directed movements relative to the endoderm. Based on the analysis of microincision experiments and computational models, we propose two characteristic, autonomous morphogenetic activities within the early myocardium: 1) an active contraction of the medial portion of the heart field and 2) curling- the tendency of the unconstrained myocardial tissue to form a spherical surface with a concave ventral side. In the intact embryo, these deformations are constrained by the endoderm and the adjacent mesoderm, nevertheless the corresponding mechanical stresses contribute to the proper positioning of myocardial primordia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.