Evidence map›Paper›PMID 25952350›Full record

ReviewOsteoarthritis and cartilage2015

OARSI Clinical Trials Recommendations: Design and conduct of clinical trials of surgical interventions for osteoarthritis.

J N Katz, E Losina, L S Lohmander

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

J N KatzDepartment of Orthopedic Surgery and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, USA. Electronic address: jnkatz@partners.org.
E LosinaDepartment of Orthopedic Surgery and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, USA.
L S LohmanderDepartment of Orthopedic Surgery, Clinical Sciences Lund, Lund University, Sweden; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Denmark; Department of Orthopedics and Traumatology, University of Southern Denmark, Denmark.
Brigham and Women's Hospital · USUniversity of Southern Denmark · DK

Funding

Trial of risk mangement for prevention of accelerated atherosclerosis in SLEP60AR047782 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KARLSON, ELIZABETH W · 2001 to 2016
$18.8M
Patient Oriented Research and Mentoring Program in OrthopedicsK24AR057827 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSINA, ELENA · 2010 to 2019
$1.7M
Molecular analysis of staphylococcal exfoliative toxin AR01AR048882 · NIAMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PLANO, LISA WILLIAMSON · 2003 to 2007
$1.4M
Randomized Trial of Non-Operative Therapies for Degenerative Meniscal TearU34AR067426 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI KATZ, JEFFREY NEIL · 2015 to 2016
$741k
NIAMS NIH HHS K24 AR057827NIAMS NIH HHS P60 AR047782NIAMS NIH HHS P60AR48882NIAMS NIH HHS R01 AR048882NIAMS NIH HHS U34 AR067426
6 · The paper itself

Abstract

To highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in the paper, we propose potential solutions. Enrollment poses challenges in maintaining investigator equipoise, managing conflict of interest and anticipating that patient preferences for specific treatments may reduce enrollment. Intervention design and implementation pose challenges relating to obsolescence, fidelity of intervention delivery, and adherence and crossover. Assessment and analysis raise questions regarding blinding and clustering of observations. This paper describes methodological problems in the design and conduct of surgical randomized trials and proposes strategies for addressing these challenges.

Indexed as

Practice Guidelines as TopicClinical Trials as TopicHumansOrthopedic ProceduresOsteoarthritisBlindingCross-overRandomized trialShamSurgery

Identifiers

PMID25952350
PMCPMC4703308
OpenAlexW2007442717

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.