Trial reportEuropean journal of nuclear medicine and molecular imaging2015
Cognitive and functional patterns of nondemented subjects with equivocal visual amyloid PET findings.
Trial report in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cross-sectional associations of amyloid burden with semantic cognition in older adults without dementia: A systematic review and meta-analysis.Mechanisms of ageing and development · 2020Pooled it
- Cognitive changes of older adults with an equivocal amyloid load.Journal of neurology · 2019Trial
- Stratifying amyloid burden in early Alzheimer's disease using cascaded attention-guided vision transformer using [¹⁸F]Florbetapir PET.European radiology · 2026Article
- Sequential scans ofJapanese journal of radiology · 2026Article
- Development and Implementation of a Radiation Safety Screening Protocol for a Clinical Study Using Amyloid Positron Emission Tomography Imaging.Ochsner journal · 2026Article
- Considerations in the clinical use of amyloid PET and CSF biomarkers for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Association between herpes simplex virus infection and Alzheimer's disease biomarkers: analysis within the MAPT trial.Scientific reports · 2025Article
- Quantitative evaluation of striatal uptake ratios using an adaptive template registration method forAnnals of nuclear medicine · 2024Article
- A Comparative Analysis of Two Automated Quantification Methods for Regional Cerebral Amyloid Retention: PET-Only and PET-and-MRI-Based Methods.International journal of molecular sciences · 2024Article
- Comparison of consistency in centiloid scale among different analytical methods in amyloid PET: the CapAIBL, VIZCalc, and Amyquant methods.Annals of nuclear medicine · 2024Article
- Phantom and clinical evaluation of the Bayesian penalised likelihood reconstruction algorithm Q.Clear without PSF correction in amyloid PET images.EJNMMI physics · 2024Article
- Toward standardization of tau PET imaging corresponding to various tau PET tracers: a multicenter phantom study.Annals of nuclear medicine · 2023Article
- Automated semi-quantitative amyloid PET analysis technique without MR images for Alzheimer's disease.Annals of nuclear medicine · 2022Article
- Visual interpretation of [European journal of nuclear medicine and molecular imaging · 2021Article
- A 4-Year Follow-Up of Subjects with Visually Equivocal Amyloid Positron Emission Tomography Findings from the Alzheimer's Disease Neuroimaging Initiative Cohort.Nuclear medicine and molecular imaging · 2021Article
- The clinical feasibility of deep learning-based classification of amyloid PET images in visually equivocal cases.European journal of nuclear medicine and molecular imaging · 2020Article
- Absence of Relationship Between Self-Reported Sleep Measures and Amyloid Load in Elderly Subjects.Frontiers in neurology · 2019Article
- Semi-quantification and grading of amyloid PET: A project of the European Alzheimer's Disease Consortium (EADC).NeuroImage. Clinical · 2019Article
- Augmenting Amyloid PET Interpretations With Quantitative Information Improves Consistency of Early Amyloid Detection.Clinical nuclear medicine · 2017Article
- The feasibility ofBrain and behavior · 2016Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDespite good to excellent inter-reader agreement in the evaluation of amyloid load on PET scans in subjects with Alzheimer's disease, some equivocal findings have been reported in the literature. We aimed to describe the clinical characteristics of subjects with equivocal PET images.
methodsNondemented subjects aged 70 years or more were enrolled from the MAPT trial. Cognitive and functional assessments were conducted at baseline, at 6 months, and annually for 3 years. During the follow-up period, 271 subjects had (18)F-AV45 PET scans. Images were visually assessed by three observers and classified as positive, negative or equivocal (if one observer disagreed). After debate, equivocal images were reclassified as positive (EP+) or negative (EP-). Scans were also classified by semiautomated quantitative analysis using mean amyloid uptake of cortical regions. We evaluated agreement among the observers, and between visual and quantitative assessments using kappa coefficients, and compared the clinical characteristics of the subjects according to their PET results.
resultsIn 158 subjects (58.30 %) the PET scan was negative for amyloid, in 77 (28.41 %) the scan was positive and in 36 (13.28 %) the scan was equivocal. Agreement among the three observers was excellent (kappa 0.80). Subjects with equivocal images were more frequently men (58 % vs. 37 %) and exhibited intermediate scores on cognitive and functional scales between those of subjects with positive and negative scans. Amyloid load differed between the EP- and negative groups and between the EP+ and positive groups after reclassification.
conclusionEquivocal amyloid PET images could represent a neuroimaging entity with intermediate amyloid load but without a specific neuropsychological pattern. Clinical follow-up to assess cognitive evolution in subjects with equivocal scans is needed.
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