Evidence map›Paper›PMID 25952256›Full record

ArticleJournal of the American Society of Nephrology : JASN2015

The Future of Polycystic Kidney Disease Research--As Seen By the 12 Kaplan Awardees.

Corinne Antignac, James P Calvet, Gregory G Germino, Jared J Grantham, Lisa M Guay-Woodford, Peter C Harris, Friedhelm Hildebrandt, Dorien J M Peters, Stefan Somlo, Vicente E Torres and 3 more

Open access · bronzeAbstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Polycystic kidney disease strikes a nerve.Physiological reports · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Knockout ofAmerican journal of physiology. Renal physiology · 2019
    Article
  15. Article
  16. Article
  17. ATP release into ADPKD cysts via pannexin-1/P2X7 channels decreases ENaC activity.Biochemical and biophysical research communications · 2019
    Article
  18. Review
  19. Article
  20. Antenatally Diagnosed ADPKD.Kidney international reports · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 4 countries.

Corinne AntignacNational Institute of Health and Medical Research, Laboratory of Inherited Kidney Diseases, Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, and The Department of Genetics, Necker Hospital, Paris, France;
James P CalvetThe Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; ayu@kumc.edu JCALVET@kumc.edu.
Gregory G GerminoKidney Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland;
Jared J GranthamThe Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas;
Lisa M Guay-WoodfordCenter for Translational Science, Children's National Health System, Washington, DC;
Peter C HarrisDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota;
Friedhelm HildebrandtHoward Hughes Medical Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts;
Dorien J M PetersDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands;
Stefan SomloDepartments of Internal Medicine and Genetics, Yale University School of Medicine, New Haven, Connecticut;
Vicente E TorresDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota;
Gerd WalzRenal Division, Department of Medicine, University Medical Center Freiburg, Freiburg, Germany; and.
Jing ZhouHarvard Center for Polycystic Kidney Disease Research, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
Alan S L YuThe Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas; ayu@kumc.edu JCALVET@kumc.edu.
University of Kansas Medical Center · USMayo Clinic · USNational Institutes of Health · USBrigham and Women's Hospital · USChildren's National · USDélégation Paris 5 · FRHôpital Necker-Enfants Malades · FRHoward Hughes Medical Institute · USYale University · US

Funding

The role of PKD proteins in regulating tubular morphologyZIADK075042 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GERMINO, GREGORY · 2010 to 2025
$23.3M
UAB Recessive PKD Research and Translational Core CenterP30DK074038 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 2005 to 2019
$16.6M
Pilot and FeasibilityP30DK090728 · NIDDK · MAYO CLINIC ROCHESTER · PI ROMERO, MICHAEL F. · 2010 to 2019
$11.8M
ADPKD:Disease Spectrum &Genotype-Phenotype CorrelationsR01DK058816 · NIDDK · MAYO CLINIC ROCHESTER · PI Peter C. Harris · 2001 to 2026
$11.3M
Transgenic and Knockout Models of ADPKDR01DK059597 · NIDDK · MAYO CLINIC ROCHESTER · PI Peter C. Harris · 2002 to 2026
$9.5M
Novel genetics, pathobiology & therapy of nephronophthisis-related ciliopathiesR01DK068306 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HILDEBRANDT, FRIEDHELM · 2004 to 2022
$6.6M
RENIN ANGIOTENSIN SYSTEM IN THE PATHOGENESIS OF ADPKDR01DK044863 · NIDDK · MAYO CLINIC ROCHESTER · PI TORRES, VICENTE E · 1991 to 2019
$4.5M
Mechanisms of Polycystin and Cilia Function in ADPKDR01DK100592 · NIDDK · YALE UNIVERSITY · PI SOMLO, STEFAN · 2013 to 2017
$1.8M
Cell biology of autosomal dominant polycystic kidney diseaseR01DK099532 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHOU, JING · 2014 to 2016
$796k
Howard Hughes Medical InstituteNIDDK NIH HHS P30 DK074038NIDDK NIH HHS P30 DK090728NIDDK NIH HHS R01 DK044863NIDDK NIH HHS R01 DK058816NIDDK NIH HHS R01 DK059597NIDDK NIH HHS R01 DK068306NIDDK NIH HHS R01 DK099532NIDDK NIH HHS R01 DK100592
6 · The paper itself

Abstract

Polycystic kidney disease (PKD) is one of the most common life-threatening genetic diseases. Jared J. Grantham, M.D., has done more than any other individual to promote PKD research around the world. However, despite decades of investigation there is still no approved therapy for PKD in the United States. In May 2014, the University of Kansas Medical Center hosted a symposium in Kansas City honoring the occasion of Dr. Grantham's retirement and invited all the awardees of the Lillian Jean Kaplan International Prize for Advancement in the Understanding of Polycystic Kidney Disease to participate in a forward-thinking and interactive forum focused on future directions and innovations in PKD research. This article summarizes the contributions of the 12 Kaplan awardees and their vision for the future of PKD research.

Indexed as

Signal TransductionAnimalsBiomedical ResearchCiliaGenes, ModifierHumansKidney TubulesMechanistic Target of Rapamycin Complex 1Microtubule-Associated ProteinsMolecular Targeted TherapyMultiprotein ComplexesPhenotypePolycystic Kidney, Autosomal DominantRenal InsufficiencyTOR Serine-Threonine KinasesTRPP Cation ChannelsMechanistic Target of Rapamycin Complex 1Microtubule-Associated ProteinsMultiprotein ComplexesTOR Serine-Threonine KinasesTRPP Cation ChannelsTTC21B protein, humangenetic renal diseasegenetics and developmentpolycystic kidney disease

Identifiers

PMID25952256
PMCPMC4552123
OpenAlexW2121760993

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.