ArticleThe Journal of physiology2015
From one generation to the next: a comprehensive account of sympathetic receptor control in branching arteriolar trees.
Article in The Journal of physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Modulatory Role of Nitric Oxide on the Vasomotor Actions of NPY in Porcine Cerebral Arteries.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Does sympathetic vasoconstriction contribute to metabolism: Perfusion matching in exercising skeletal muscle?Frontiers in physiology · 2022Review
- Hyperinsulinemia does not cause de novo capillary recruitment in rat skeletal muscle.Microcirculation (New York, N.Y. : 1994) · 2020Article
- Dipeptidyl Peptidase IV as a Muscle Myokine.Frontiers in physiology · 2020Review
- Neuropeptide Y1 and alpha-1 adrenergic receptor-mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice.Physiological reports · 2018Article
- Endogenous dipeptidyl peptidase IV modulates skeletal muscle arteriolar diameter in rats.Physiological reports · 2018Article
- The superoxide dismutase mimetic tempol does not alleviate glucocorticoid-mediated rarefaction of rat skeletal muscle capillaries.Physiological reports · 2017Article
- Altered distribution of adrenergic constrictor responses contributes to skeletal muscle perfusion abnormalities in metabolic syndrome.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Exercise training and α1-adrenoreceptor-mediated sympathetic vasoconstriction in resting and contracting skeletal muscle.Physiological reports · 2016Article
- The stress of maternal separation causes misprogramming in the postnatal maturation of rat resistance arteries.American journal of physiology. Heart and circulatory physiology · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of the sympathetic nervous system on blood flow distribution within skeletal muscle microvasculature is conditional upon regional activation of receptors for sympathetic neurotransmitters. Previous studies have shown that proximal arterioles are largely governed by adrenergic activation, whereas it is speculated that distal branches are controlled by peptidergic and purinergic activation. However, no study has systematically evaluated the activation of adrenergic, peptidergic and purinergic receptors in continuously branching arteriolar trees of an individual skeletal muscle model. Therefore, in the present study, sympathetic agonists were used to evaluate the constriction responses along first to fifth order arterioles in continuously branching arteriolar trees of a in vivo rat gluteus maximus muscle preparation with respect to specific activation of receptors for sympathetic neurotransmitters (α1R, α2R, NPY1R and P2X1R). Constriction responses were incorporated into a mathematical blood flow model to estimate the total flow, resistance and red blood cell flow heterogeneity within a computationally reconstructed gluteus maximus arteriolar network. For the first time, the effects of activating receptors for sympathetic neurotransmitters on vasoconstrictor responses and the ensuing haemodynamics in continuously branching arteriolar trees of skeletal muscle were characterized, where proximal arterioles responded most to α1R and α2R adrenergic activation, whereas distal arterioles responded most to Y1R and P2X1R activation. Total flow and resistance changed with activation of all receptors, whereas red blood cell flow heterogeneity was largely affected by peptidergic and purinergic activation in distal arterioles. The reported data highlight the functional consequences of topologically-dependent sympathetic control and may serve as novel input parameters in computational modelling of network flow.
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