ArticleBMC oral health2015
Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes.
Article in BMC oral health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Oral microbiome alterations in individuals with type 1 diabetes: a systematic review.Clinical oral investigations · 2026Pooled it
- Candida species detection in patients with chronic periodontitis: A systematic review and meta-analysis.Clinical and experimental dental research · 2022Pooled it
- Dental caries prevention as a modifiable precipitating factor of nephrotic syndrome relapse in children: an insight into simple-novel management.International urology and nephrology · 2025Article
- Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus-A Comprehensive Review of Clinical Studies.International journal of molecular sciences · 2024Review
- Review
- Infectious diseases associated with pediatric type 1 diabetes mellitus: A narrative review.Frontiers in endocrinology · 2022Review
- Oro-Dental Health and Primary Nephrotic Syndrome among Vietnamese Children.Children (Basel, Switzerland) · 2021Article
- Clinical Characteristics and Relevance of OralJournal of fungi (Basel, Switzerland) · 2021Article
- Oral health conditions in children with idiopathic nephrotic syndrome: a cross-sectional study.BMC oral health · 2020Article
- Prevalence and antifungal susceptibility of gastrointestinal candidiasis among diabetic patients: A cross-sectional study.African journal of laboratory medicine · 2020Article
- Candida sp. Infections in Patients with Diabetes Mellitus.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiabetes and Nephrotic syndrome (NS) promote plaque-related gingivitis and yeast-like fungal infections. The study assesses the impact of Candida spp. and general disease- or treatment-related factors on plaque-related gingivitis severity in children and adolescents with Nephrotic syndrome /diabetes.
methodsBody mass index (BMI), BMI standard deviation score, and oral cavity (Plaque Index--PLI, Gingival Index--GI, mucosa status, presence and Candida enzymatic activity) were assessed in 96 patients (32 with NS: 30- immunosuppressive treatment, 35--type 1 diabetes, and 29 generally healthy), aged; 3-18 years. Laboratory included cholesterol and triglyceride measurements; in diabetic subjects- glycated haemoglobin, in NS: total protein, albumin, creatinine, haemoglobin, haematocrit, white cell count, urinary protein excretion. Medical records supplied information on disease duration and treatment. A statistical analysis was performed; Kendall Tau coefficient, chi-square test, t-test, and multiple regression analysis ( P < 0.05).
resultsCandida spp. often occurred in healthy patients, but oral candidiasis was found only in the NS and diabetes groups (9.37% and 11.43%). Gingivitis occurred more frequently in patients with NS/diabetes. Gingivitis severity was correlated with PLI, age, and yeast enzyme activity in NS--to with immunosuppressive treatment with >1 drug, drug doses, treatment duration, lipid disorders, and BMI; in diabetes, with blood glucose and glycated haemoglobin >8%.
conclusionPoor hygiene control is the main cause of gingivitis. Gingivitis severity is most likely related to age, lipid disorders and increase in body mass. Candida spp., in uncompensated diabetes and in those using immunosuppressive treatment, might intensify plaque-related gingivitis.
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