ArticleThe Journal of allergy and clinical immunology2015
Measuring the corticosteroid responsiveness endophenotype in asthmatic patients.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator.The Journal of allergy and clinical immunology · 2018Trial
- Features of asthma which provide meaningful insights for understanding the disease heterogeneity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Trial
- Machine Learning Prediction of Treatment Response to Inhaled Corticosteroids in Asthma.Journal of personalized medicine · 2024Article
- Article
- Heterogeneity of Treatment Response to Asthma.Advances in experimental medicine and biology · 2023Article
- CASTER: Cross-Sectional Asthma STEroid Response Measurement.Journal of personalized medicine · 2020Article
- Severe T2-high asthma in the biologics era: European experts' opinion.European respiratory review : an official journal of the European Respiratory Society · 2019Review
- Precision medicine and phenotypes, endotypes, genotypes, regiotypes, and theratypes of allergic diseases.The Journal of clinical investigation · 2019Review
- Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007-2012.Clinical and translational allergy · 2018Article
- Asthma remission: Predicting future airways responsiveness using an miRNA network.The Journal of allergy and clinical immunology · 2017Article
- Whole genome prediction and heritability of childhood asthma phenotypes.Immunity, inflammation and disease · 2016Article
- Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression.American journal of physiology. Lung cellular and molecular physiology · 2016Article
- Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.The journal of allergy and clinical immunology. In practiceArticle
- Identification of Asthma Subtypes Using Clustering Methodologies.Pulmonary therapyReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInhaled corticosteroids are the most commonly used controller therapies for asthma, producing treatment responses in 6 clinical phenotypes: lung function, bronchodilator response, airway responsiveness, symptoms, need for oral steroids and frequency of emergency department visits and hospitalizations. We hypothesize that treatment response in all of these phenotypes is modulated by a single quantitative corticosteroid responsiveness endophenotype.
objectiveWe sought to develop a composite phenotype that combines multiple clinical phenotypes to measure corticosteroid responsiveness with high accuracy, stability across populations, and robustness to missing data.
methodsWe used principal component analysis to determine a composite corticosteroid responsiveness phenotype that we tested in 4 replication populations. We evaluated the relative accuracy with which the composite and clinical phenotypes measure the endophenotype using treatment effect area under the receiver operating characteristic curve (AUC).
resultsIn the study population the composite phenotype measured the endophenotype with an AUC of 0.74, significantly exceeding the AUCs of the 6 individual clinical phenotypes, which ranged from 0.56 (P < .001) to 0.67 (P = .015). In 4 replication populations with a total of 22 clinical phenotypes available, the composite phenotype AUC ranged from 0.69 to 0.73, significantly exceeded the AUCs of 14 phenotypes, and was not significantly exceeded by any single phenotype.
conclusionThe composite phenotype measured the endophenotype with higher accuracy, higher stability across populations, and higher robustness to missing data than any clinical phenotype. This should provide the capability to model corticosteroid pharmacologic response and resistance with increased accuracy and reproducibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.