Evidence map›Paper›PMID 25951836›Full record

ReviewPhysics in medicine and biology2015

Functional optical coherence tomography: principles and progress.

Jina Kim, William Brown, Jason R Maher, Howard Levinson, Adam Wax

Abstract readReview
In one paragraph

Review in Physics in medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Journal of biomedical optics · 2025
    Article
  5. Review
  6. Advancements in nanotheranostics for glioma therapy.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Intelligent optical diagnosis and treatment system for automated image-guided laser ablation of tumors.International journal of computer assisted radiology and surgery · 2021
    Article
  20. A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jina KimDepartment of Surgery, Duke University, Durham, NC 27710, USA.
William BrownDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Jason R MaherDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.
Howard LevinsonDepartment of Surgery, Duke University, Durham, NC 27710, USA.
Adam WaxDepartment of Biomedical Engineering, Duke University, Durham, NC 27708, USA.

Funding

Novel Determination of Microbicide PK in Women's Reproductive HealthR01HD072702 · NICHD · DUKE UNIVERSITY · PI KATZ, DAVID FRANK · 2012 to 2015
$1.8M
Coherent light scattering for early detection of retinal diseaseR21EY023451 · NEI · DUKE UNIVERSITY · PI WAX, ADAM · 2013 to 2014
$417k
NEI NIH HHS 1R21EY023451NEI NIH HHS R21 EY023451NICHD NIH HHS R01 HD072702
6 · The paper itself

Abstract

In the past decade, several functional extensions of optical coherence tomography (OCT) have emerged, and this review highlights key advances in instrumentation, theoretical analysis, signal processing and clinical application of these extensions. We review five principal extensions: Doppler OCT (DOCT), polarization-sensitive OCT (PS-OCT), optical coherence elastography (OCE), spectroscopic OCT (SOCT), and molecular imaging OCT. The former three have been further developed with studies in both ex vivo and in vivo human tissues. This review emphasizes the newer techniques of SOCT and molecular imaging OCT, which show excellent potential for clinical application but have yet to be well reviewed in the literature. SOCT elucidates tissue characteristics, such as oxygenation and carcinogenesis, by detecting wavelength-dependent absorption and scattering of light in tissues. While SOCT measures endogenous biochemical distributions, molecular imaging OCT detects exogenous molecular contrast agents. These newer advances in functional OCT broaden the potential clinical application of OCT by providing novel ways to understand tissue activity that cannot be accomplished by other current imaging methodologies.

Indexed as

Contrast MediaSignal Processing, Computer-AssistedTomography, Optical CoherenceContrast Media

Identifiers

PMID25951836
PMCPMC4448140

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.