Evidence map›Paper›PMID 25950919›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2015

Trends in treatment and in-hospital mortality for neonates with congenital diaphragmatic hernia.

J I Hagadorn, E A Brownell, K W Herbst, J M Trzaski, S Neff, B T Campbell

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differences in mortality characteristics in neonates with Down's syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2017
    Article
  9. Observational
  10. Congenital Diaphragmatic hernia - a review.Maternal health, neonatology and perinatology · 2017
    Review
  11. Review
  12. New Horizon in Understanding of Pediatric Surgical Diseases.Journal of Indian Association of Pediatric Surgeons
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

J I HagadornDivision of Neonatology, Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.
E A BrownellDivision of Neonatology, Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.
K W HerbstDepartments of Pediatric Urology and Research, Connecticut Children's Medical Center, Hartford, CT, USA.
J M TrzaskiDivision of Neonatology, Department of Pediatrics, University of Connecticut School of Medicine, Farmington, CT, USA.
S NeffDepartments of Pediatric Urology and Research, Connecticut Children's Medical Center, Hartford, CT, USA.
B T CampbellDepartment of Pediatric Surgery, Connecticut Children's Medical Center, Hartford, CT, USA.
University of Connecticut · USConnecticut Children's Medical Center · USUConn Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe performed a retrospective cohort study in order to examine recent trends in use of post-partum treatments and in-hospital mortality for congenital diaphragmatic hernia (CDH). STUDY

designIncluded were infants with CDH, born in 2003 to 2012 and hospitalized at ⩽7 days of age at one of 33 United States tertiary referral children's hospitals with extracorporeal membrane oxygenation (ECMO) programs. In-hospital mortality as well as use of ECMO, surfactant and a variety of vasodilators were examined for trends during the study period.

resultInclusion criteria were met by 3123 infants with CDH. Among 2423 term or near-term infants, odds of death decreased annually for those with isolated or complex CDH. For 700 premature or low-birth weight infants with CDH, in-hospital mortality did not change. Among treatments for CDH, increasing with time in the study cohort were use of milrinone and sildenafil individually, and use of multiple vasodilators during the hospitalization.

conclusionSurvival improved in large subgroups of term or near-term infants with CDH in this 10-year multicenter cohort, temporally associated with increasing use of multiple vasodilators. Use of vasodilators for infants with CDH is increasing despite a lack of evidence supporting efficacy or safety. Prospective research is needed to clarify specific causal effects contributing to improving survival in these infants.

Indexed as

Extracorporeal Membrane OxygenationHernias, Diaphragmatic, CongenitalCohort StudiesFemaleHospital MortalityHospitals, PediatricHumansInfant, Low Birth WeightInfant, NewbornMaleMortalityPulmonary SurfactantsRetrospective StudiesTerm BirthUnited StatesVasodilator AgentsPulmonary SurfactantsVasodilator Agents

Identifiers

PMID25950919
OpenAlexW1489866010

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.