ArticleJournal of perinatology : official journal of the California Perinatal Association2015
Depth of bacterial invasion in resected intestinal tissue predicts mortality in surgical necrotizing enterocolitis.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The trial behind it
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Who cites it
42 citing papers in PubMed, 62 citations in OpenAlex.
- "Necrotizing enterocolitis": a paradigm shift.Pediatric research · 2026Article
- Epigenetic changes associated with severe necrosis and survival in preterm infants with surgical necrotizing enterocolitis.Pediatric research · 2026Article
- Necrotizing enterocolitis.Nature reviews. Disease primers · 2026Review
- Targeted immune response gene expression profiles linked with necrosis and mortality in preterm infants with surgical necrotizing enterocolitis.World journal of pediatric surgery · 2026Article
- Distinct microbiota profiles in non-survivors in preterm infants with surgical necrotizing enterocolitis: Insights from FFPE intestinal tissue analysis.Journal of neonatal-perinatal medicine · 2025Article
- Multi-strain probiotic administration decreases necrotizing enterocolitis severity and alters the epigenetic profile in mice.Pediatric research · 2025Article
- Bedside Utilization of Intestinal Pathology in Preterm Infants with Surgical Necrotizing Enterocolitis.American journal of perinatology · 2025Review
- Platelet specific knockout of integrin beta-3 (β3) reduces severity of necrotizing enterocolitis in murine neonates.Frontiers in pediatrics · 2025Article
- Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention.Life (Basel, Switzerland) · 2024Article
- Clinical and Growth Correlates of Retinopathy of Prematurity in Preterm Infants with Surgical Necrotizing Enterocolitis and Intestinal Perforation.American journal of perinatology · 2024Article
- Association of timing of surgery and outcomes in preterm infants with surgical necrotizing enterocolitis and intestinal perforation.Journal of neonatal-perinatal medicine · 2024Article
- Clinical correlates of cerebellar injury in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2024Article
- Clinical Correlates of Cerebellar Injury in Preterm Infants with Surgical Necrotizing Enterocolitis.Research square · 2023Article
- Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates.BMJ paediatrics open · 2023Review
- Clinical determinants of intestinal failure and death in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2023Article
- Clinical determinants and impact of hemorrhagic lesions on intestinal pathology in preterm infants with surgical necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2023Article
- Clinical and histopathological correlates of intestinal repair in preterm infants following surgical necrotizing enterocolitis.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022Article
- Bench to bedside - new insights into the pathogenesis of necrotizing enterocolitis.Nature reviews. Gastroenterology & hepatology · 2022Review
- Clinical outcomes and gestational age based prediction of pneumatosis intestinalis in preterm infants with necrotizing enterocolitis.Journal of neonatal-perinatal medicine · 2022Article
- Role of macrophages in fetal development and perinatal disorders.Pediatric research · 2021Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveUp to a third of all infants who develop necrotizing enterocolitis (NEC) require surgical resection of necrotic bowel. We hypothesized that the histopathological findings in surgically resected bowel can predict the clinical outcome of these infants. STUDY
designWe reviewed the medical records and archived pathology specimens from all patients who underwent bowel resection/autopsy for NEC at a regional referral center over a 10-year period. Pathology specimens were graded for the depth and severity of necrosis, inflammation, bacteria invasion and pneumatosis, and histopathological findings were correlated with clinical outcomes.
resultWe performed clinico-pathological analysis on 33 infants with confirmed NEC, of which 18 (54.5%) died. Depth of bacterial invasion in resected intestinal tissue predicted death from NEC (odds ratio 5.39 per unit change in the depth of bacterial invasion, 95% confidence interval 1.33 to 21.73). The presence of transmural necrosis and bacteria in the surgical margins of resected bowel was also associated with increased mortality.
conclusionDepth of bacterial invasion in resected intestinal tissue predicts mortality in surgical NEC.
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