ReviewNeuron2015
Brains, genes, and primates.
Erratum issuedAbstract readReview
In one paragraph
Review in Neuron, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 151 papers.
0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
151 citing papers in PubMed.
- Genome-wide association study of emotional empathy in children.Scientific reports · 2020Trial
- A scalable touchscreen-based spatial working memory task for cross-species research.Neurobiology of learning and memory · 2026Article
- Combining phase analysis and causal stimulation enables longitudinal mesoscale connectivity mapping.bioRxiv : the preprint server for biology · 2026Article
- The primate claustrum as a hub for precision weighting of prediction errors across the cortical hierarchy.PLoS biology · 2026Article
- Highly consistent anatomical asymmetry in a small primate brain: left is always larger in the marmoset monkey.Communications biology · 2026Article
- A Scalable Touchscreen-Based Spatial Working Memory Task for Cross-Species Research.bioRxiv : the preprint server for biology · 2026Article
- Targeted gene transfer into developmentally defined cell populations of the primate brain.Cell reports · 2026Article
- Trends of laboratory nonhuman primate licensing in China between 2020 and 2024: A national database analysis.PloS one · 2026Article
- Deciphering Neural Mechanisms Underlying Marmoset Dynamic Natural Behaviors Using a Miniaturized Wireless Large-Scale Coverage Neural Recorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Slow wave electroencephalogram spectral properties during adaptation of a new light dark cycle in cynomolgus monkeys.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Methylene blue treatment of fatal cerebral malaria and identification of potential blood biomarkers.Nature communications · 2025Article
- A Multimodal Atlas Reveals the Anatomical Distribution of Medium Spiny Neuron Subtypes and a Novel RGS6+ Population in the Primate Striatum.bioRxiv : the preprint server for biology · 2025Article
- Establishment of a second-generation transgenic marmoset with germline transmission that models polyglutamine disease.Disease models & mechanisms · 2025Article
- Optogenetic modulation of long-range cortical circuits in awake nonhuman primates.Nature protocols · 2025Review
- Isolation, Identification, and Drug Sensitivity Test ofVeterinary sciences · 2025Article
- A stealthy neural recorder for the study of behaviour in primates.Nature biomedical engineering · 2025Article
- Article
- Advancement in modeling of Alzheimer's disease: a comprehensive review of preclinical screening platforms.Frontiers in aging neuroscience · 2025Review
- Epigenomic landscapes during prefrontal cortex development and aging in rhesus.National science review · 2024Article
- Parallel patterns of cognitive aging in marmosets and macaques.bioRxiv : the preprint server for biology · 2024Article
91 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
21 authors.
Juan Carlos Izpisua BelmonteGene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Edward M CallawaySystems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Sarah J CaddickThe Gatsby Charitable Foundation, The Peak, 5 Wilton Road, London SW1V 1AP, UK.
Patricia ChurchlandDepartment of Philosophy, University of California, San Diego, 1500 Gilman Drive, La Jolla, CA 92093, USA.
Guoping FengDepartment of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, Cambridge, MA 02139, USA.
Gregg E HomanicsDepartment of Anesthesiology and Pharmacology and Department of Chemical Biology, University of Pittsburgh, 6060 Biomedical Science Tower 3, Pittsburgh, PA 15261, USA.
Kuo-Fen LeeClayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
David A LeopoldSection on Cognitive Neurophysiology and Imaging, Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20192, USA.
Cory T MillerDepartment of Psychology and Neurosciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Jude F MitchellBrain and Cognitive Sciences, Meliora Hall, Box 270268, University of Rochester, Rochester, NY 14627-0268, USA.
Shoukhrat MitalipovCenter for Embryonic Cell and Gene Therapy, Oregon Health and Science University, 3303 S.W. Bond Avenue, Portland, OR 97239, USA; Division of Reproductive and Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, 505 N.W. 185th Avenue, Beaverton, OR 97006, USA.
Alysson R MoutriSchool of Medicine, Department of Pediatrics/Rady Children's Hospital San Diego, and Department of Cellular and Molecular Medicine, Stem Cell Program, 9500 Gilman Drive, La Jolla, CA 92093, USA.
J Anthony MovshonCenter for Neural Science, New York University, New York, NY 10003, USA.
Hideyuki OkanoDepartment of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; Laboratory for Marmoset Neural Architecture, Brain Science Institute RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
John H ReynoldsSystems Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: reynolds@salk.edu.
Dario RingachDepartment of Neurobiology and Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 92093, USA.
Terrence J SejnowskiComputational Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Afonso C SilvaLaboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 49 Convent Drive, MSC 1065, Building 49, Room 3A72, Bethesda, MD 20892-1065, USA.
Peter L StrickBrain Institute and Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA; Research Service, Department of Veterans Affairs Medical Center, Pittsburgh, PA 15261, USA.
Jun WuGene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Feng ZhangBroad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, 43 Vassar Street, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 7 Massachusetts Avenue, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, 7 Massachusetts Avenue, Cambridge, MA 02139, USA; Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA 02142, USA.
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Ye Zheng · 1985 to 2026
$82.8MSpatial-Temporal Characterization of The Hemodynamic Response to Neural ActivityZIANS003041 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SILVA, AFONSO · 2009 to 2019
$17.1MVisual Adaptation and Neuronal SelectivityZIAMH002898 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LEOPOLD, DAVID A · 2009 to 2025
$13.6MIsogenic Human Pluripotent Stem Cell-Based Models of Human Disease MutationsR01DK097768 · NIDDK · BROAD INSTITUTE, INC. · PI COWAN, CHAD ALBERT, ZHANG, FENG · 2012 to 2016
$11.0MResourceP40OD010996 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STRICK, PETER · 2012 to 2024
$11.0MPREMOTOR AREAS IN THE FRONTAL LOBER01NS024328 · NINDS · UPSTATE MEDICAL UNIVERSITY · PI STRICK, PETER · 1987 to 2015
$8.9MNeural basis of vocal signal recognition during natural communicationR01DC012087 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CORY T MILLER · 2012 to 2026
$5.7MMassively-parallel functional interrogation of psychiatric geneticsR01MH110049 · NIMH · BROAD INSTITUTE, INC. · PI ZHANG, FENG · 2015 to 2019
$5.5MProbing Neuropsychiatric Diseases Using Targeted Epigenome and Genome EngineeringDP1MH100706 · NIMH · BROAD INSTITUTE, INC. · PI ZHANG, FENG · 2012 to 2016
$4.3MHistocompatible Primate Embryonic Stem CellsR01HD057121 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2009 to 2013
$3.4MMitochondrial Gene TherapyR01HD063276 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI MITALIPOV, SHOUKHRAT · 2010 to 2014
$3.0MHoward Hughes Medical InstituteIntramural NIH HHSNCCDPHP CDC HHS 5DP1-MH100706NCI NIH HHS P30 CA014195NEI NIH HHS R01 EY021214NEI NIH HHS R01-EY021214NEI NIH HHS R01 EY021827NICHD NIH HHS R01 HD057121NICHD NIH HHS R01-HD057121NICHD NIH HHS R01 HD059946NICHD NIH HHS R01-HD059946NICHD NIH HHS R01 HD063276NICHD NIH HHS R01-HD063276NIDCD NIH HHS R01 DC012087NIDDK NIH HHS 5R01-DK097768NIDDK NIH HHS R01 DK097768NIH HHS 1-DP2-OD006495-01NIH HHS DP2 OD006495NIH HHS P40 OD010996NIH HHS P51 OD011092NIH HHS P51-OD011092NIMH NIH HHS DP1 MH100706NIMH NIH HHS R01 MH110049NIMH NIH HHS R21 MH104756NINDS NIH HHS P30 NS076405NINDS NIH HHS R01 NS024328NINDS NIH HHS R01 NS24328
Abstract
One of the great strengths of the mouse model is the wide array of genetic tools that have been developed. Striking examples include methods for directed modification of the genome, and for regulated expression or inactivation of genes. Within neuroscience, it is now routine to express reporter genes, neuronal activity indicators, and opsins in specific neuronal types in the mouse. However, there are considerable anatomical, physiological, cognitive, and behavioral differences between the mouse and the human that, in some areas of inquiry, limit the degree to which insights derived from the mouse can be applied to understanding human neurobiology. Several recent advances have now brought into reach the goal of applying these tools to understanding the primate brain. Here we describe these advances, consider their potential to advance our understanding of the human brain and brain disorders, discuss bioethical considerations, and describe what will be needed to move forward.
Indexed as
GenesAnimalsBiological EvolutionBrainHumansMiceModels, BiologicalPrimates
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.