ArticlePLoS genetics2015
Parallel Gene Expression Differences between Low and High Latitude Populations of Drosophila melanogaster and D. simulans.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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64 citing papers in PubMed, 141 citations in OpenAlex.
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- Adaptive gene expression parallelism in the male reproductive tract of two Drosophila species.Genetics · 2025Article
- Phylogenetic Relatedness Does not Predict Patterns of Parallel Transcriptome Adaptation in Drosophila.Genome biology and evolution · 2025Article
- No Evidence of Sexually Antagonistic Coevolution in Drosophila Reproductive Tract Transcriptomes.Molecular biology and evolution · 2025Article
- Sex-Biased Gene Expression Under Sexually Antagonistic and Sex-Limited Selection.Molecular biology and evolution · 2025Article
- Reduced Parallel Gene Expression Evolution With Increasing Genetic Divergence-A Hallmark of Polygenic Adaptation.Molecular ecology · 2025Article
- Intraspecific gene regulation in cis- and trans.Evolution; international journal of organic evolution · 2025Review
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- Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.PLoS genetics · 2025Article
- Regional specialization, polyploidy, and seminal fluid transcripts in theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Comparative Transcriptomic Reveals Greater Similarities in Response to Temperature Than to Invasive Alien Predator in the DamselflyEvolutionary applications · 2024Article
- Molecular Mechanisms of Temperature Tolerance Plasticity in an Arthropod.Genome biology and evolution · 2024Article
- Experimental Evolution in a Warming World: The Omics Era.Molecular biology and evolution · 2024Review
- Heat tolerance, oxidative stress response tuning and robust gene activation in early-stageProceedings. Biological sciences · 2024Article
- Selection and geography shape male reproductive tract transcriptomes in Drosophila melanogaster.Genetics · 2023Article
- The roles of divergent and parallel molecular evolution contributing to thermal adaptive strategies in trees.Plant, cell & environment · 2022Article
- Ecological Speciation Promoted by Divergent Regulation of Functional Genes Within African Cichlid Fishes.Molecular biology and evolution · 2022Article
- A soybean non-coding RNA mining and co-expression resource based on 1,596 RNA-seq and small RNA-seq libraries.Plant physiology · 2022Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Gene expression variation within species is relatively common, however, the role of natural selection in the maintenance of this variation is poorly understood. Here we investigate low and high latitude populations of Drosophila melanogaster and its sister species, D. simulans, to determine whether the two species show similar patterns of population differentiation, consistent with a role for spatially varying selection in maintaining gene expression variation. We compared at two temperatures the whole male transcriptome of D. melanogaster and D. simulans sampled from Panama City (Panama) and Maine (USA). We observed a significant excess of genes exhibiting differential expression in both species, consistent with parallel adaptation to heterogeneous environments. Moreover, the majority of genes showing parallel expression differentiation showed the same direction of differential expression in the two species and the magnitudes of expression differences between high and low latitude populations were correlated across species, further bolstering the conclusion that parallelism for expression phenotypes results from spatially varying selection. However, the species also exhibited important differences in expression phenotypes. For example, the genomic extent of genotype × environment interaction was much more common in D. melanogaster. Highly differentiated SNPs between low and high latitudes were enriched in the 3' UTRs and CDS of the geographically differently expressed genes in both species, consistent with an important role for cis-acting variants in driving local adaptation for expression-related phenotypes.
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