ArticleHuman brain mapping2015
A common gustatory and interoceptive representation in the human mid-insula.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 3 syntheses or guidelines pooled it, 102 citations in OpenAlex.
- A Systematic Review and Activation Likelihood Estimation Meta-Analysis of fMRI Studies on Sweet Taste in Humans.The Journal of nutrition · 2020Pooled it
- Building the bodily self-awareness: Evidence for the convergence between interoceptive and exteroceptive information in a multilevel kernel density analysis study.Human brain mapping · 2020Pooled it
- Basic taste processing recruits bilateral anteroventral and middle dorsal insulae: An activation likelihood estimation meta-analysis of fMRI studies.Brain and behavior · 2017Pooled it
- Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex.Scientific reports · 2021Trial
- Obesity is associated with altered mid-insula functional connectivity to limbic regions underlying appetitive responses to foods.Journal of psychopharmacology (Oxford, England) · 2017Trial
- When does post-ingestive dopamine signaling occur in humans?bioRxiv : the preprint server for biology · 2026Article
- Assessing health, wellbeing, and working life impacts of a 4-day week: a multimodal protocol.Frontiers in psychology · 2026Article
- Rewiring the Brain Through the Gut: Insights into Microbiota-Nervous System Interactions.Current issues in molecular biology · 2025Review
- Insular Cortex Modulation by Repetitive Transcranial Magnetic Stimulation with Concurrent Functional Magnetic Resonance Imaging: Preliminary Findings.Brain sciences · 2025Article
- Separating Subjective from Objective Food Value in the Human Insula: An Exploratory Study Using Intracranial EEG.Brain sciences · 2025Article
- A multicenter cross-sectional study to elucidate altered resting-state functional connectivity of the insular cortex in anorexia nervosa, segmented by functional localization.Scientific reports · 2025Article
- Functional movement disorder is associated with abnormal interoceptive brain activity: a task-based functional MRI study.Frontiers in psychiatry · 2025Article
- Bilateral insular cortical lesions reduce sensitivity to the adverse consequences of acute ethanol intoxication in Pavlovian conditioning procedures.Alcohol, clinical & experimental research · 2024Article
- Functional Movement Disorder Is Associated with Abnormal Interoceptive Brain Activity: A Task-based Functional MRI Study.medRxiv : the preprint server for health sciences · 2024Article
- Structural and functional asymmetry of the neonatal cerebral cortex.Nature human behaviour · 2023Article
- A common neural code for representing imagined and inferred tastes.Progress in neurobiology · 2023Article
- Intrinsic functional clustering of the macaque insular cortex.Frontiers in integrative neuroscience · 2023Article
- Increased insula response to interoceptive attention following mindfulness training is associated with increased body trusting among patients with depression.Psychiatry research. Neuroimaging · 2022Article
- An insula hierarchical network architecture for active interoceptive inference.Royal Society open science · 2022Review
- Allostasis, Action, and Affect in Depression: Insights from the Theory of Constructed Emotion.Annual review of clinical psychology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
The insula serves as the primary gustatory and viscerosensory region in the mammalian cortex. It receives visceral and gustatory afferent projections through dedicated brainstem and thalamic nuclei, which suggests a potential role as a site for homeostatic integration. For example, while human neuroimaging studies of gustation have implicated the dorsal mid-insular cortex as one of the primary gustatory regions in the insula, other recent studies have implicated this same region of the insula in interoception. This apparent convergence of gustatory and interoceptive information could reflect a common neural representation in the insula shared by both interoception and gustation. This idea finds support in translational studies in rodents, and may constitute a medium for integrating homeostatic information with feeding behavior. To assess this possibility, healthy volunteers were asked to undergo fMRI while performing tasks involving interoceptive attention to visceral sensations as well as a gustatory mapping task. Analysis of the unsmoothed, high-resolution fMRI data confirmed shared representations of gustatory and visceral interoception within the dorsal mid-insula. Group conjunction analysis revealed overlapping patterns of activation for both tasks in the dorsal mid-insula, and region-of-interest analyses confirmed that the dorsal mid-insula regions responsive for visceral interoception also exhibit strong responses to tastants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.