ArticleBrain injury2015
Prevalence and predictors of affective lability after paediatric traumatic brain injury.
Article in Brain injury, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Irritability in stroke: a protocol for a prospective study.Frontiers in neurology · 2024Article
- Emotional Regulation and Adolescent Concussion: Overview and Role of Neuroimaging.International journal of environmental research and public health · 2023Review
- Diffusion in the corpus callosum predicts persistence of clinical symptoms after mild traumatic brain injury, a multi-scanner study.Frontiers in neuroimaging · 2023Article
- Usability and validity of a virtual reality cognitive assessment tool for pediatric traumatic brain injury.Rehabilitation psychology · 2022Article
- A Systematic Scoping Review of New Attention Problems Following Traumatic Brain Injury in Children.Frontiers in neurology · 2021Article
- Clinical characteristics of patients with bipolar disorder and premorbid traumatic brain injury: a cross-sectional study.International journal of bipolar disorders · 2018Article
- Variation in PPP3CC Genotype Is Associated with Long-Term Recovery after Severe Brain Injury.Journal of neurotrauma · 2017Article
- Functional neuroimaging of traumatic brain injury: advances and clinical utility.Neuropsychiatric disease and treatment · 2015Review
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Authors and funding
8 authors.
Funding
Abstract
objectivePaediatric severe traumatic brain injury (TBI) is associated with significant post-injury affective and behavioural problems. Few studies have examined the prevalence and characteristics of affective lability after paediatric TBI.
methodsNinety-seven children with severe TBI were evaluated 1 year post-injury for the presence of affective lability using the Children's Affective Lability Scale (CALS). Demographic, clinical and brain lesion characteristics were also assessed.
resultsAffective lability significantly increased after injury. Eighty-six children had a pre-injury CALS score of 1 SD or less from the group pre-injury mean (M = 8.11, SD = 9.31), of which 35 and 15 children had a 1 SD and 2 SD increase in their CALS score from pre- to post-injury, respectively. A variety of affective shifts manifested post-injury including anxiety, silliness, dysphoria and irritability. The most severe symptoms were irritability and unpredictable temper outbursts. Risk factors for affective lability included elevated pre-injury affective lability and psychosocial adversity as well as greater damage to the orbitofrontal cortex. Post-injury affective lability was most frequently associated with a post-injury diagnosis of attention-deficit hyperactivity disorder.
conclusionsAffective lability is common after paediatric TBI and frequently manifests as irritability and unpredictable outbursts. Early intervention is needed to improve psychiatric outcomes.
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