ArticleScientific reports2015
Single-cell evaluation of red blood cell bio-mechanical and nano-structural alterations upon chemically induced oxidative stress.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- High titres of IgM-bound circulating immune complexes and erythrocytic oxidative damage are indicators of dengue severity.Clinical and experimental immunology · 2019Trial
- Sustained low micromolar hydrogen peroxide exposure induces sequential red blood cell dysfunction.Frontiers in physiology · 2026Article
- An analysis of occupational exposure to particulate matter and erythrocyte morphological abnormalities among charcoal-grill restaurant workers.Frontiers in public health · 2026Article
- Analysis of erythrocyte deformation characteristics based on dual-angle Mueller matrix measurement.Frontiers of optoelectronics · 2025Article
- Gray Frequency-Based Methodology for Assessing Cell Damage.ACS omega · 2025Article
- Synthesis and toxicity of monothiooxalamides against human red blood cells, brine shrimp (Heliyon · 2024Article
- Assessment of Red Blood Cell Aggregation in Preeclampsia by Microfluidic Image Flow Analysis-Impact of Oxidative Stress on Disease Severity.International journal of molecular sciences · 2024Article
- Article
- Oxidative Stress in Healthy and Pathological Red Blood Cells.Biomolecules · 2023Review
- Putative Contribution of 8-Aminoquinolines to Preventing Recrudescence of Malaria.Tropical medicine and infectious disease · 2023Article
- RedTell: an AI tool for interpretable analysis of red blood cell morphology.Frontiers in physiology · 2023Article
- Protection of Erythrocytes and Microvascular Endothelial Cells against Oxidative Damage byMolecules (Basel, Switzerland) · 2022Article
- The Nutraceuticals as Modern Key to Achieve Erythrocyte Oxidative Stress Fighting in Osteoarthritis.Current issues in molecular biology · 2022Review
- Changes in Blood Cell Deformability in Chorea-Acanthocytosis and Effects of Treatment With Dasatinib or Lithium.Frontiers in physiology · 2022Article
- Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Frontiers in cellular and infection microbiology · 2022Review
- The Toxic Influence of Excess Free Iron on Red Blood Cells in the Biophysical Experiment: An In Vitro Study.Journal of toxicology · 2022Article
- Microfluidic Characterization of Red Blood Cells Microcirculation under Oxidative Stress.Cells · 2021Article
- Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin.Redox biology · 2021Article
- How the spleen reshapes and retains young and old red blood cells: A computational investigation.PLoS computational biology · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erythroid cells, specifically red blood cells (RBCs), are constantly exposed to highly reactive radicals during cellular gaseous exchange. Such exposure often exceeds the cells' innate anti-oxidant defense systems, leading to progressive damage and eventual senescence. One of the contributing factors to this process are alterations to hemoglobin conformation and globin binding to red cell cytoskeleton. However, in addition to the aforementioned changes, it is possible that oxidative damage induces critical changes to the erythrocyte cytoskeleton and corresponding bio-mechanical and nano-structural properties of the red cell membrane. To quantitatively characterize how oxidative damage accounts for such changes, we employed single-cell manipulation techniques such as micropipette aspiration and atomic force microscopy (AFM) on RBCs. These investigations demonstrated visible morphological changes upon chemically induced oxidative damage (using hydrogen peroxide, diamide, primaquine bisphosphate and cumene hydroperoxide). Our results provide previously unavailable observations on remarkable changes in red cell cytoskeletal architecture and membrane stiffness due to oxidative damage. Furthermore, we also demonstrate that a pathogen that infects human blood cells, Plasmodium falciparum was unable to penetrate through the oxidant-exposed RBCs that have damaged cytoskeleton and stiffer membranes. This indicates the importance of bio-physical factors pertinent to aged RBCs and it's relevance to malaria infectivity.
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