Evidence map›Paper›PMID 25950023›Full record

ArticleJournal of veterinary medicine and research2014

EFFECT OF LIPOSOMAL CLODRONATE-DEPENDENT DEPLETION OF PROFESSIONAL ANTIGEN PRESENTING CELLS ON NUMBERS AND PHENOTYPE OF CANINE CD4+CD25+FOXP3+ REGULATORY T CELLS.

Kriston F Weaver, John V Stokes, Sagen A Gunnoe, Joyce S Follows, Lydia Shafer, Mais G Ammari, Todd M Archer, John M Thomason, Andrew J Mackin, Lesya M Pinchuk

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of veterinary medicine and research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kriston F WeaverDepartment of Basic Sciences, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, MS 39762, USA.
John V StokesDepartment of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, 240 Wise Center Drive, Mississippi State, MS 39762, USA.
Sagen A Gunnoe
Joyce S Follows
Lydia Shafer
Mais G Ammari
Todd M Archer
John M Thomason
Andrew J Mackin
Lesya M Pinchuk
Mississippi State University · US

Funding

Summer Research Experience for Veterinary StudentsT35OD010432 · OD · MISSISSIPPI STATE UNIVERSITY · PI Barbara Lee-Faubert Kaplan, Temesgen Samuel · 2012 to 2026
$1.3M
NIH HHS T35 OD010432
6 · The paper itself

Abstract

Regulatory T cells (Tregs) are known to control autoreactivity during and subsequent to the development of the peripheral immune system. Professional antigen presenting cells (APCs), dendritic cells (DCs) and monocytes, have an important role in inducing Tregs. For the first time, this study evaluated proportions and phenotypes of Tregs in canine peripheral blood depleted of professional APCs, utilizing liposomal clodronate (LC) and multicolor flow cytometry analysis. Our results demonstrate that LC exposure promoted short term decreases followed by significant increases in the proportions or absolute numbers of CD4

Indexed as

Antigen Presenting CellsLiposomal ClodronateMonocytesRegulatory T cells

Identifiers

PMID25950023
PMCPMC4418640
OpenAlexW2400273060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.